I am CBS +/+… I just took a Sulfite urine strip test and my level's were >1600 (greater than 1600) the highest reference level it reads. However, Some of my lab's contradict what is seen in CBS up regulation and was wondering if anyone had any insight as how this shakes out.
My homocystine is in the upper normal range
My cystine is right in the middle Normal
Sulfate levels high on urine strip
However, my cystathionine, and I may be wrong one this might need some wisdom on this the test (amino acid blood results) reads >dl for the result (nothing else read's this I think it means low?) But if I'm right how can my cystine be low but cystathionine normal? As cystathionine upstream from cystine.
My ammonia levels are just slightly elevated above the middle still well in reference range
However my Taurine levels are completely normal.. Everything I've read said they should be low?
However even with the "methyl dump" of CBS taking SAM-E even at 100 mg is very stimulating for me. Along with methyl b12 and methyl folate at doses 300 mcg's and up.
I am also confused on why my methionine is higher, and how that relates to the CBS. Because everything on the main cycle is high except for SAME I'm a little confused on where my block is at.
My mutations are as follows…(post viral fatigue since Aug 12' 24 yr. old Male)
+/+ MAO A ….. CBS (C699T) …..SHMT…...
ACAT +/-
--------------------
MTHFR (C677T) +/-
--------------------
MTR (A2756G) +/_
--------------------
MTRR (A66G) +/-
--------------------
MTRR(11) +/-
--------------------
BHMT 2 +/-
--------------------
BHMT 4 +/-
--------------------
BHMT 8 +/-
--------------------
CBS (A360A) +/-
Methylation Pathway Panel
Glutathione (oxidized) 0.58 (.16-0.50)
Glutathione (reduced) 3.8 (3.8-5.5)
----------------------------------------------------
SAM-E… 223 (221-256)
SAH……. 56.4 (38-49)
--------------------------------------------------
5-CH3-THF …….….14.3 (8.4-72.6)
10-Formyl-THF…. 8.5 (1.5-8.2)
5-Formyl-THF…….2.0 (1.20-11.7)
THF……………………0.67(.60-6.80)
Folic Acid…………..16.6 (8.9-24.6)
Folinic Acid (WB)..10.2 (9.0-35.5)
Active Folate…… 361 (400-1500)
----------------------------------------------------
Adenosine ……….26.9 (16.8-21.4)
Borderline high Methionine 3.3 (1.6-3.6) per Amino Acid Plasma
Borderline High Homocystine .41 (<.50)
However my Ammonia isn’t bad 18 (<30)
My homocystine is in the upper normal range
My cystine is right in the middle Normal
Sulfate levels high on urine strip
However, my cystathionine, and I may be wrong one this might need some wisdom on this the test (amino acid blood results) reads >dl for the result (nothing else read's this I think it means low?) But if I'm right how can my cystine be low but cystathionine normal? As cystathionine upstream from cystine.
My ammonia levels are just slightly elevated above the middle still well in reference range
However my Taurine levels are completely normal.. Everything I've read said they should be low?
However even with the "methyl dump" of CBS taking SAM-E even at 100 mg is very stimulating for me. Along with methyl b12 and methyl folate at doses 300 mcg's and up.
I am also confused on why my methionine is higher, and how that relates to the CBS. Because everything on the main cycle is high except for SAME I'm a little confused on where my block is at.
My mutations are as follows…(post viral fatigue since Aug 12' 24 yr. old Male)
+/+ MAO A ….. CBS (C699T) …..SHMT…...
ACAT +/-
--------------------
MTHFR (C677T) +/-
--------------------
MTR (A2756G) +/_
--------------------
MTRR (A66G) +/-
--------------------
MTRR(11) +/-
--------------------
BHMT 2 +/-
--------------------
BHMT 4 +/-
--------------------
BHMT 8 +/-
--------------------
CBS (A360A) +/-
Methylation Pathway Panel
Glutathione (oxidized) 0.58 (.16-0.50)
Glutathione (reduced) 3.8 (3.8-5.5)
----------------------------------------------------
SAM-E… 223 (221-256)
SAH……. 56.4 (38-49)
--------------------------------------------------
5-CH3-THF …….….14.3 (8.4-72.6)
10-Formyl-THF…. 8.5 (1.5-8.2)
5-Formyl-THF…….2.0 (1.20-11.7)
THF……………………0.67(.60-6.80)
Folic Acid…………..16.6 (8.9-24.6)
Folinic Acid (WB)..10.2 (9.0-35.5)
Active Folate…… 361 (400-1500)
----------------------------------------------------
Adenosine ……….26.9 (16.8-21.4)
Borderline high Methionine 3.3 (1.6-3.6) per Amino Acid Plasma
Borderline High Homocystine .41 (<.50)
However my Ammonia isn’t bad 18 (<30)