New era for ME/CFS research as top cytokine study attracts media headlines
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CBS A360A & alpha lipoic acid supplements

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by BadBadBear, Jul 12, 2014.

  1. BadBadBear

    BadBadBear Senior Member

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    Rocky Mountains
    Hi,

    I have recently had my 23AndMe results run, and one of the outcomes is homozygous for
    CBS A360A. This makes sense to me because at times, I cannot handle sulfur containing foods. I had never put it together as a sulfur problem until now, though. I go through stretches where the freshest eggs from my own backyard flock taste HORRIBLE and sulfurous to me, and other times they taste sooo good, so I think this may be A360A in action.

    Before finding out about A360A, I had recently started supplementing ALA (200mg slow release form) and find it helps me a lot with nocturia and my 4 a.m. glucogenesis cycle. I am not waking up and having adrenaline spurts, and that change was immediate with ALA supplementation. Sometimes I sleep all night, which is a huge blessing.

    So my question is, if you have this mutation and took/take ALA, how did it work for you? Are there other supplements that might be similar in action to ALA w/o the -thiol content? And if I do something like stop eating eggs & cruciferous veggies (which I have done), will that help offset staying on ALA or is it not worth the risk?

    I do make cinnamon tea daily for blood sugar, and between that and ALA, my fasting glucose is down 10 points or so. Enough to bump me down into a normal range for my morning blood sugars (75-90).

    Thanks for any thoughts or advice or random pondering about this. :)

    - Michelle

    ps. FWIW, my terrible flare-up in 2012 happened when I was consuming a lot of sulfur foods - whey & kefir smoothies, crucifers, eggs. I have never found a reason for that flare, this seems like a very possible cause as I went on to become completely protein intolerant for a long time after that, and I can still barely tolerate kefir (which I make for my celiac DH as it seems to tremendously benefit him).
     
  2. shah78

    shah78 Senior Member

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    st pete , florida
    I'm bewildered by your ability to handle ALA but unable to handle high sulfur food. Google Andrew Cutler Chelation. ALA is Uber-high sulfur. Always interesting things to learn here on PH.
     
  3. BadBadBear

    BadBadBear Senior Member

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    Rocky Mountains
    I am in a phase now where eggs are not bothering me, so I would guess that is why I am tolerating ALA. That said, I do feel like my gut dysbiosis has been on the rise lately.
     
  4. BadBadBear

    BadBadBear Senior Member

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    Rocky Mountains
    OHHHH, would build up of ammonia cause my BUN level to be high?? Or would there be some other blood marker I could look back at in my older bloodwork? I do have an elevated BUN for some reason. Hmmm.

    To update this post, I was reading yesterday and found info on a website about blood test lab procedure that high ammonia can cause a falsely high BUN.
     
    Last edited: Jul 13, 2014
  5. BadBadBear

    BadBadBear Senior Member

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    Rocky Mountains
    Hmmm. So I tested serum ammonia, and it's at 42 (range 30-124). Homocystine is too low at 5.01 (range 4.44-13.56). I also got my sulfur strips in and my sulfur level is basically undetectable.

    I'm confused now. Do I need to add thiols back in? Am I over-methylated? My gut is doing much better, but I'm not sure if it's the low sulfur diet or the resistant starch.
     

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