Many of us know carnitine helps produce energy in the mitochondria, this article took it a step further and discussed the significance of adding lipoic acid. "Dynamic Duo: Carnitine and Lipoic Acid There is no question that supplementing with any carnitine formulation enhances the mitochondrial use of fatty acids, thus making more energy available to cells and tissues, enhancing their various functions,5 and slowing the mitochondrial damage that leads to aging.2,6,7 However, the very increase of electron flow associated with this more efficient use of fatty acid energy may itself lead to increased formation of reactive oxygen species.2 The solution to this dilemma, according to a research review released in 2002, is co-supplementation with lipoic acid. Lipoic acid is a natural cofactor for a mitochondrial enzyme that is critical in breaking down fatty acids, which may further enhance cellular energy efficiency. In addition, lipoic acid is a potent antioxidant that increases intracellular levels of vitamin C and glutathione, which are powerful antioxidants in their own right.8,9 By adding lipoic acid to carnitine, scientists have reversed age-related decline in laboratory animals while further reducing oxidative stress.2 This "one-two punch" of carnitine and lipoic acid helps to knock out the oxidative stress that occurs with high energy utilization." I wonder who here takes these together regularly, and does it help significantly? Link below.