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Carmine Pariante's MRC research award-Persistent fatigue induced by interferon-alpha

Discussion in 'General ME/CFS News' started by Dolphin, Dec 21, 2011.

  1. Sean

    Sean Senior Member

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    It is pretty well all she (and a few others) have. They have largely built their careers and reputations on it, so if it turns out to be wrong or trivial, then ignominy and irrelevancy loom for them.


    Some of the usual suspects in there. :whistle:
     
  2. Esther12

    Esther12 Senior Member

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    Maybe of interest:

    http://journals.cambridge.org/actio...0091&fulltextType=RV&fileId=S0033291713002468
     
  3. Firestormm

    Firestormm

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    what constitutes a 'childhood stressor'? And can it include persistent viral infections as a kid?
     
  4. Dolphin

    Dolphin Senior Member

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    Not for many of them anyway.

    Here's a sample from a CDC study:


    .​



    Free full text:
    http://archpsyc.jamanetwork.com/article.aspx?articleid=668231

    One of the big problems in this study was it used the empiric criteria (2.54% of the population, picks a lot who likely simply have depression).
     
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  5. Dolphin

    Dolphin Senior Member

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    I've started a specific thread on this paper here:
    http://forums.phoenixrising.me/index.php?threads/childhood-stressors-in-the-development-of-fatigue-syndromes-a-review-of-past-20-years-of-research.25698/
     
    Esther12 likes this.
  6. Firestormm

    Firestormm

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    Childhood stress not a likely trigger for MS: http://www.medpagetoday.com/MeetingCoverage/ECTRIMS/42093

    5 October 2013

     
    Esther12 and Dolphin like this.
  7. Fred1234567

    Fred1234567

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    How hard is it for the Uk to study ME/CFS - the neurological disease with the weird metabolic characteristics and stress receptors as found by the USA and Australian scientists?
    The disease defined by the CCC and the ICC criteria needs independent studies until biomarkers are found. Once biomarkers are found for the disorincr disease cohort then where the diagnostic line is will be clear.
    At the moment studying an unclear soup of fatigue patients and not those with post exertional malaise the core diagnostic marker of Me/CFS is harming people.
     
    Cinders66 likes this.
  8. Fred1234567

    Fred1234567

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    Childhood stressors or not is immaterial what is needed is biomarkers? How can you pretend to know if childhood stressors are relevant when you don't even know how to distinguish the disease from other diseases with similar symptoms.
     
    IreneF likes this.
  9. Esther12

    Esther12 Senior Member

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    I don't think that this paper, funded from this grant, has been published on PR yet:

    Childhood trauma and adulthood inflammation: A meta-analysis of peripheral C-reactive protein, Interleukin-6 and Tumour Necrosis Factor-α

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564950/

     
    Valentijn likes this.
  10. wastwater

    wastwater Senior Member

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    So if you have been blitzed with interferon even when it's stopped you can still suffer persistent fatigue and it only applies to a minority
     

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