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Cardiac mast cells: the centrepiece in adverse myocardial remodelling

Discussion in 'Mast Cell Disorders/Mastocytosis' started by Sherlock, Jan 7, 2015.

  1. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002871/

     
  2. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    @Countrygirl

    Which might also relate to the gender difference in CFS.
    .
     
  3. Countrygirl

    Countrygirl I'm with Cheesus

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    I have just noticed the above in your signature. For many years, my tendons have easily torn and now I have tenosynovitis and De Quervains (both thumbs) in my hands. Is this connected?

    This has really puzzled me as I have been bed/sofa/house bound for most of the last 35 years so wear-and-tear cannot explain my sudden wide spread arthritis, including hips, knees, spine and hands. Are you then saying that this could be a result of a mast cell disorder?

    And it explains the malignant hypertension?

    What about fibrosis of the skin? (very rare, but I have it and, believe me, if ME is horrid, this is worse.)

    I think I need to study mast cell disorders.:(
     
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  4. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    @Countrygirl

    Yes, Mast Cells make the protein dissolving enzymes chymase and tryptase, which can attack joints. Fibrosis of the skin might very well be the remodeling as in that study's title, also related to mast cells.

    If you drag a fingernail across the skin of your chest, does that leave a line? (dermatographia)
     
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  5. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    @Countrygirl
    If you were to take 500mg of niacin and flush tremendously (I do), that would be a sign of a mast cell problem, because of the excess histamine involved. (IF you can handle that experiment.)

    Then in the next one or two days, you'd take quercetin a half hour before and repeat the niacin - for me that almost completely prevents the flush. I had posted some time ago on this subforum some study that said that quercetin works better than prescription drugs.

    For me, tart cheery works even better to stabilize the mast cells and prevent them from releasing their inflammatory contents.
     
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  6. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    Here's one from back in 1995 with mice and skin fibrosis:
    The role of mast cells in the development of skin fibrosis in tight-skin mutant mice.
    https://www.ncbi.nlm.nih.gov/pubmed/7704626
    from 2007, again with mice (because they can create mice with no mast cells)
    Mast cells and immunological skin diseases.
     
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  7. Countrygirl

    Countrygirl I'm with Cheesus

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    Thank you for all your replies, Sherlock. I have some studying to do.

    Many thanks and if you can point me in the direction of other useful articles, that would be great. Thank you.
     
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  8. ahmo

    ahmo Senior Member

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    @Countrygirl I was just typing this as yours posted. try mastcellmaster.com Many research papers, + vids from expert Dr. Theoharides.
     
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  9. Countrygirl

    Countrygirl I'm with Cheesus

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    Thanks ahmo. I am also going to read the thread here on ME as a possible Mast Cell disorder.

    I wonder if this is why Dr Bell wrote many years ago that all his ME patients had a history of allergies such as hayfever and asthma? Do any of us not have a childhood history of allergy?
     
  10. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    I did not.

    Do you happen to have a history of bad reactions to bee stings?

    The MTHFR SNP?
     
  11. Countrygirl

    Countrygirl I'm with Cheesus

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    @Sherlock @ahmo I am finding this very revealing so far and had no idea that mast cells played (possibly)such a role in my health problems since I was a child. I also have bronchiectasis and glomerulonenephritis and apparently both are thought to be associated with a mast cell activation disorder. Even the exercise-induced hives that I developed when a child is a sign of the over-activity of mast cells. I didn't know anyone else had such an odd reaction to running (those were the days!) Then there are the brown stains on the skin...........................

    I don't know if this makes sense, but I had no problems until I had a deep bite by a guinea pig which triggered my first asthma attack and a very itchy rash. From then on I became allergic to so many things, even sun light which causes a rash. The guinea pig died just after she bit me. I think my blood must have poisoned her.
     
  12. Countrygirl

    Countrygirl I'm with Cheesus

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    I have never been stung by a bee, so don't know. I reacted badly to an insect bite (may have been a tick) when I was a student and developed ME shortly after that, but I also had a tetanus jab, and suspect that played a role in suppressing the immune system. I then developed encephalitis from which I never seemed to recover fully.
     
  13. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    :woot: :)

    I think there are two types of people here: those with weak immunity whose main problem is active infections

    and then those mainly with overactive immunity (like me and probably you)

    This could be a real milestone for you. I hope it is. Btw, I'd once read that Mast cells were originally called Master cells because they control so much.

    Mast cell tryptases and chymases in inflammation and host defense
    http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/17498057/

    Mast cells and inflammation
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318920/

    Immunomodulation of mast cells by nutrients. 2015
    http://www.ncbi.nlm.nih.gov/pubmed/24524883
    Abstract

    In the past decades an increasing prevalence of allergic disorders was observed in industrialized countries. Thus, it is necessary to develop adequate therapeutic and preventive strategies. Many of the conservative strategies possess diverse harmful side effects. Therefore agents with fewer side effects and a better compliance among afflicted patients would be of interest. Especially substances with natural origin acting immunomodulatory on mast cells - the key effector cells of allergic diseases - could be used. Among them there are components of the daily diet such as distinct fatty acids and amino acids as well as a range of secondary plant substances such as carotenoids, flavonoids and spices. These nutritional substances could be applied as nutraceuticals in the therapy of mast cell associated diseases. Many of these substances show inhibitory influences on the release of prestored mast cell mediators such as histamine or de novo expression of mast cell mediators such as cytokines and eicosanoids which are involved in the pathogenesis of mast cell associated inflammatory conditions like allergic reactions.


    But I now think I was wrong about what is done by the histamine receptors on MCs - I think that they are meant to inhibit more histamine secretion. But what if they go haywire?
     
  14. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    I had a bad cold 6 years ago, which is what set it all off for me.

    Sun sensitivity is definitely involved om some immune conditions (lupus is the most famous).
     
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  15. ahmo

    ahmo Senior Member

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    @Countrygirl Until I started following the pr Mast Cell forum, I knew nothing of them. I only become aware of my significant histamine issues when I went gluten free and started the GAPS diet 3 years ago. I'd had persistent urticaria for years, but before that could only attribute it to pharmaceuticals. From histamine to mast cells, I've since learned that some of my unexplained symptoms are indeed mast cell. They each seem small, but they form a pattern, and seem to be getting more active without my constant vigilance: small ulcer-like lesions in nostrils and ears, waxy exudate "sprayed" in my ears, crystal-like feeling in corners of upper eyes, blood blisters in mouth, and urinary urgency. I think my blotchy skin probably fits in here, altho I've heard a recent description that puts it into a fungal category.

    There's a very close connection to adrenal health. When my adrenals are stressed, MC symptoms appear. I've learned a lot from lowhistaminechef.com, although I don't use any of her recipes. Quercetin, royal jelly, rutin, mangosteen, luteolin all are helpful. I now use the symptoms as a monitor to how my system is faring. And I self-test for more of the supps when things are activated. I've also been thrilled with the + effects of Theorharides' formula Neuroprotek, to stop the histamine cascade in the brain. I resisted it when first hearing about it, too expensive...but I've found it fabulous. And it's shown me that when my mind is stuck in a constant chatter mode, I can take one of these and calm it down within 15 minutes.

    I don't have a very deep understanding of MC, though enough to cope with my symptoms. However, I'm concerned that there might well be a tendency to increase over time, into some of the more alarming areas, like cardiac, or anaphalyxis. I've been taking low dose naltrexone (LDN) for about 5 months, with greatly increased stamina. I hope maybe some of its benefits spill over into mast cells. I also have over-active, auto-immunity.
     
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  16. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    Just two nights ago, I had gotten into bed and pulled a heavy blanket across myself. I felt an immediate stab of sharp pain - I had given myself a bad sprain in that thumb. It's taped now as I type this.

    (I remember the term De Quervain syndrome because I had researched that last year.)

    Last year, my right index finger was so bad and vulnerable that just clicking my mouse injured it some more. So i started using the laptop's touchpad left-mouse button with my left hand instead. There are times when I can't open a tin can -- unless I do it sort of reversed and backwards. My right wrist has been fairly crippled since early December.

    I'm mentioning all this so you can compare :)
     
  17. Countrygirl

    Countrygirl I'm with Cheesus

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    Six years! You're a mere babe!

    Thank you for all the great info you have posted for me to read, but it is time for bed here in the UK, so will read it tomorrow. It is very interesting and is new information to me.

    A scientist well known to us explained to me that we have a immune deficiency syndrome which puzzled me as I haven't been able to produce the symptoms of a cold for 35 years, since the ME became severe. My immune system appears to kill a virus at fifty paces, which makes me think it is on high alert. In fact, I have no doubt that ME, although destroying my life, yet saved it as the bronchiectasis which is in both lungs was life threatening whenever I had a cold. ME preserved my lungs from further damage.However, I cannot fight bacterial and fungal infections and antibiotics can make me ill, so I guess that reflects a deficiency.

    I must hit the hay so will 'see' you tomorrow. Nite, nite! :)
     
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  18. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    check and check
    have you tried anti-inflammatories (like ibuprofen) for the latter? I then get up only every 4 hours instead of every 2 hours (but I don't want to take them every night). Alkalizing strategies like Potassium Citrate capsules also help.

    I have recently been very surprised that tart cheery is very anti-anxiety for me.
     
  19. Countrygirl

    Countrygirl I'm with Cheesus

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    Snap!!! Literally! I'm sorry you have this problem too. My tendons react in the same way and are easily damaged. The De Quervain's is intensely painful when it is severe and the thumbs cannot be moved even a quarter inch. I now have to ask the shop assistants to open bottles for me when I buy them and ask passers by to open tins and containers when I need them. Thumbs are very useful........when they work and how I miss them!

    I also now have osteopenia and I see that is also listed as part of a mast cell problem.

    And I still haven't hit the hay!
     
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  20. Countrygirl

    Countrygirl I'm with Cheesus

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    I am going to study your post tomorrow as it is too late for me now to think straight. Thank you for sharing this and I look forward to reading it carefully when my grey cell is in a better state.:) I find it fascinating and sounds very familiar and it is good to know we are not alone.:hug:

    Nite, nite...............again.
     
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