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Can't shut my brain off to sleep

Discussion in 'Sleep' started by minkeygirl, Feb 1, 2014.

  1. Aileen

    Aileen Senior Member

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    I've never heard of Tizanidine so I looked it up. Glad I did. According to Wikipedia it belongs to a class of meds called centrally acting (meaning CNS, so neurons likely involved) alpha 2 (a2) andrenergic agonists.

    Since I have migraines and have tried most migraine preventatives, I'm happy to learn of this. Also my current muscle relaxant is now only available in generic which does not seem to be working. Hmm...

    It says that alpha 2 receptors are involved in the sympathetic nervous system. It looks like this class of drugs mimics the actions epinephrine (adrenalin) and/or norepinephrine (noradrenalin) in various ways. Agonists increase or inhanse the effect.

    There is a list of other drugs in the same class so perhaps you should look at others in that category. Maybe you can find one that will work like the tizanidine but without the problems you are having.

    Perhaps someone with better knowledge of these drugs could comment.
    WoolPippi likes this.
  2. minkeygirl

    minkeygirl Senior Member

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    Didn't know. I can't read what you wrote or if I could wouldn't remember.

    Try baclofen. Also a muscle relaxant. Used to amp me up. Doesn't seem to be doing much of anything now.
  3. Soundthealarm21

    Soundthealarm21 Senior Member

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    Haha I burst out laughing. Thanks for that.
  4. minkeygirl

    minkeygirl Senior Member

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    I still laugh every time I think of that!
  5. Aerose91

    Aerose91 Senior Member

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    I have the same problem as you but mine is due to benzo withdrawal damage. I took ativan for sleep for 10 days 2 years ago and i never recovered. I went into SEVERE withdrawal and though it is better 2 years later, i still have "weapons grade insomnia" as you speak of. i am awake completely redlined all night.

    I would recommend being very careful with the benzos if you decide to go that route.
  6. minkeygirl

    minkeygirl Senior Member

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    I didn't sleep more than 2 hours a night for a year after I took 4 months titrating off 1 mg of Klonopin. So I know.

    If I do do a benzo, it would only be halcion which has a 3 hour half life and is easy to get off, if you mean not sleeping for 3 day is easy. But I love benzos too much so I'm not sure I even want them around. That would be as a last resort.
  7. Soundthealarm21

    Soundthealarm21 Senior Member

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    You took a drug for ten days and still have withdrawals 2 years later? That is nuts!

    I've been taking klonopin 1mg for a while now. Whenever i've had to stop it for an extended period of time I have never had any sort of a withdrawal. I guess i'm a lucky one with that.

    I've only ever been addicted or had withdrawals to two things. Cigarettes and Welbutrin (only took this one for 4 days, and it made me feel like a heroin addict coming off).
  8. minkeygirl

    minkeygirl Senior Member

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    Protracted withdrawal can happen but that does seem odd. How much were you on? Ativan is one of the nastier ones though. Worse IMO than Klonopin or Xanax to get off of.
  9. Soundthealarm21

    Soundthealarm21 Senior Member

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    I've stopped 1mg of Klonopin cold turkey for a period of 6 months with absolutely no problems. I've taken Ativan 1mg before. I've actually still got one of those pills in a bottle somewhere. I've only had to up the dose one time from .5mg to 1mg because of tolerance, but I've been on 1mg since last May without needing anymore.

    When we thought my problems were "mental" I was sent to Sierra Tucson which is a drug rehab place and mental health facility. I saw so many people coming off benzos and the horrors of tapering that came with it. I'm just glad I don't have to deal with that. I've got enough problems as it is!
  10. minkeygirl

    minkeygirl Senior Member

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  11. Aerose91

    Aerose91 Senior Member

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    Yes only 2 weeks. I believe the
    problem was that A) they strted me.on 2.5 mg when id never taken benzos before, B) i cold turkey'd because they told me that it was safe within that time frame, and C) i was taking hydrocortisone at the same time for severe adrenal fatigue and later came to find out that steroids are cross reactive with benzos.

    The first couple months post c/t i slept about 5 hours per week, had 24 hour long panic attacks, thick derealization, was huddled in a corner uncontrollably shaking, only saw black and white, helleucinated uncontrollably, had psychosis (i thought i had been abducted from earth and put on another planet), couldnt tell the difference between hot or cold, lights and sounds were so harsh i had to sit silently in a blacked out room with sunglasses on, and an unexplanable, unrelenting anxiety.

    I have a list somewhere of my symptoms and it was somewhere around 80, those ones i listed are just a few that i remember off the top of my head.

    Although im better, many still persist today 2 years later,the worst being insomnia. Its not just insomnia though, i dont just lay awake, i lay in full blown fight or flight mode for 6-8 hours so by the time i get out of bed in the morning im so much more worn out than i was when i went to bed. i have basically been in a perpetual state of sleep deprivation this whole time but i cant take anything because i am so ungodly sensitive to everything now. I had an immunologist give me a nasal spray with epinephrine in it last year and i went right back into acute withdrawal with all the anxiety, tremors, halleucinations, fear, etc. for about 2 months. So yeah, i think i can figure out why i got M.E.
  12. Soundthealarm21

    Soundthealarm21 Senior Member

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    Oh my gosh that is so horrible. I wish I knew what to say :cry:
  13. Leopardtail

    Leopardtail Senior Member

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    What method do you use to stabilise blood sugars Plum?
  14. Leopardtail

    Leopardtail Senior Member

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    Aerose,

    have your levels of Cortisol & Thyroid hormones been checked?
    Do you ever fever when infected?
    Do you have infective symtpoms?

    L.
  15. Aerose91

    Aerose91 Senior Member

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    @Leopardtail yes i have all my hormones checked regularly. My cortisol and thyroid are slightly low but not clinical hypothyroid or addisons level. I got M.E. from encephalitis so i never felt fluish like a lot of people describe since i never had the flu. I have swollen lymph nodes and feel slightly fluish sometimes but those are far from my worst symptoms.

    @Soundthealarm21
    Thats very kind of you, nothing to do really, the damage has been done and i just have to hope that in the next few years i can make a little more of a recovery.
  16. Leopardtail

    Leopardtail Senior Member

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    okay, just wondered about the Cortisol due to your high blood sugar and sleeping issues...
    BTW was your Cortisol checked just in the morning, or was it checked several times?
    Some people with ME have lowered morning, raised at night, messes up sleep cycles and reverse it..
  17. Aerose91

    Aerose91 Senior Member

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    I do 5 times/day saliva tests. its highest in morning, low afternoon and evening and climbs a bit again at night. Not to crazy levels tho and i used to sleep much better than this even with adrenal fatigue.

    The crazy blood sugar problems ive been having recently have been because of a period of overexertion, it changed something- what i dont know- but ive been like this ever since. Per is my usual, all of my PEM setbacks have been permenant.
  18. Mya Symons

    Mya Symons Mya Symons

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    I have found a few supplements that work well for me to shut off the brain. Maybe they'll work for you?:

    1) Jarrow GABA Soothe (from Vitacost.com, 30 Caps)
    Ingredients
    a. Gamma-aminobutyric Acid (GABA) (PharmaGABA); 100mg
    b. Theanine (Suntheanine); 100mg
    c. Sensoril (Ashwagandha extract) (roots/leaves) (Withania somnifera); 225mg

    2) 5-HTP & Melatonin ( Swanson’s, 30 Caps)
    Ingredients
    a. L-5 HTP (L-5 hydroxytryptophan) (Griffonia simplicifolia seed extract); 50 mg
    b. Melatonin; 3 mg

    3) Phosphatidyl Serine Complex (Vitacost, 120 Sgels)
    Ingredients
    a. SerinAid® (Standardized to 20% phosphatidylserine); 1000 mg
    b. Phosphatidylserine; 200 mg
    c. Phosphatidylcholine; 90 mg
    d. Phosphatidylethanolamine; 20 mg

  19. Leopardtail

    Leopardtail Senior Member

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    Aerose,

    I am seeing quit a lot of questions about blood sugar regulation on the threads here but my answers are spread across many threads. The answer you have given here and the question you posted about diabetes may well be related. In answer to the question in your diabetes post I created a thread and posted a link to it. Would you mind pulling together the information here, and the question about diabetes in that thread?

    I am going to try and start pulling this information together so its easier for people to benefit from it. It's an area where the quality of research has been poor, hence it takes some explaining.

    Your diabetes question above.

    Link to thread above.
    .
  20. xrayspex

    xrayspex Senior Member

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    u.s.a.
    did you say if you ever tried remeron? i took that one summer like 12 years ago and man that knocks you black out -out, to where u might not get up til the next aft....

    i also have weird things happen from valtrex....dont know what you do about that--didnt cause insomnia but pain flare

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