The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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Cant methylate zinc and folate, what to do??

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by dazzle22, May 21, 2015.

  1. dazzle22


    Hi there,

    I just got my results from a saliva methylationtest back. It says i have one gene mutation called C677 that causes me not being able to methylate zinc or folate. Unfortunatly i have no idea what to do about it and when i google i can't really find anything specific for this gene mutation.

    Im pretty desperate and was hoping someone in here has an idea of how i can fix this issue and get to better health? If you know something please let me know, i would be so grateful.

    I don't know if this matters, but one thing i realised is, when i take high dosage of b12(mecobalamin 500 microgram) or also a few other b vitamines im so wired and can't hold still for like 1-2 hours, its like i drank 10 coffees.

    I added a picture of the test result below in case that matters.

    Thanks a lot for looking at my thread,

    Attached Files:

  2. PeterPositive

    PeterPositive Senior Member

    the mutation you have is fairly common, almost 45% of the population has one MTHFR mutation. This doesn't necessarily translate into a health issue.

    Also this type of tests don't tell you if your methylation is really working or not. To assess that you should perform a functional test that looks at the end products of the cycle, such as reduced glutathione and SAMe.

    These tests are available in labs like this (it's called the methylation panel)

    All the test is telling you, is that you may need an extra bit of active folate (methylfolate) in your diet or via supplementation.

    If taking methyl-B12 gives you such a bad reaction I would avoid it. Replacing it with hydroxy-B12 could also work.

    Last edited: May 22, 2015
    helen1 and Valentijn like this.

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