@LynnJ: start with about 2500mcg AdB12. See how that does you. Work up or down from there. I got a big boost from AdB12 immediately. Hope you have the same response. Doesn't matter if you take adb12 and mb12 at the same time. They're fine together. I don't think it matters if you take sublingual B12 on empty stomach or not. It diffuses into the tissues. You shouldn't be swallowing your B12's at all (either form). Most of it will get wasted in your stomach acid that way. Both adb12 and mb12 should be taken between cheek and gums and held for at least an hour. I take my folate with a little food but not much. I read it's better on a more empty stomach but completely empty isn't necessary. I actually take it with a glass of milk but realize not everyone can drink milk. My point is that folate should probably be taken with a very light snack. Jarrow changed within the last year or two.