Hi, My mum has rheumatoid arthritis and I'm trying to help her get on the methylation protocol. She takes methotrexate with which they prescribe folic acid (not folate), in 5 mg daily doses as methotrexate can deplete folate. I have the MTHFR polymorphism (+/-) so I want to assume my mum has that too and get her to switch to folate. My question is whether you are pretty much able to substitute methylfolate / folinic acid for folic acid at a similar dosage level, eg 5mg? She spoke to her doctor about this who (surprise, surprise) didn't know anything about it, but did agree to getting her homocysteine level checked. I don't know if there are any other alternatives to methotrexate that she could look into, since depleting folate doesn't sound like a good idea. Hope this question is ok since I know it doesn't specifically relate to CFS, but I thought this would be the best place to ask. Hope someone can help, thank you.