I have had fatigue for 24 years. On the odd occasion I had to take a day or two off work, but because I have an extroverted personality, I have been able to hide my fatigue well. However, after taking Modafinil for the first time for 6 days in February, getting no benefit, then stopping, my fatigue got much worse (I actually got balance problems while on Modafinil which 'became' the greater fatigue once stopped, 6 weeks ago). My tiredness is such now that I am often in bed & can hardly get anything done. I have never had muscle soreness after exercise. I have never had depression or come close. I have had rare bouts of irritable bowel syndrome, but often get severe stomach cramps and diarrhoea. I just learnt IBS has some correlation with CFS, so I just started taking B.Infantis last week I had a brain MRI 2 weeks ago and it's very healthy. Blood tests over the 24 years have always been clear (eg: iron, thyroid, blood cell count, rheumatoid factor, etc, etc) I went on CPAP 3 years ago but it has made marginal difference (the 'second opinion' sleep/respiratory physician I recently saw, reviewed my sleep study and said that my Obstructive Sleep Apnea was so marginal, I could do without CPAP). I very rarely get 'sick', so I have had a suspicion that I have had a long term overactive immune system (hyper-immunity?) and incidentally I recently was diagnosed with possible rheumatoid arthritis which does involve the immune system attacking the body and tiredness is a symptom. I did test positive for the gene HLA-B27 which is common in people with rheumatoid arthritis. That said, the rheumatologist feels that I don't have it, as the joint problems are marginal and haven't deteriorated. Regardless, the Modafinil was the catalyst for significant fatigue. Any suggestions? By the way, is insomnia not uncommon with CFS? I have this annoying problem, of 'waking up' later in the day, after being fatigued all day and being able to do more in the evening It's really, really frustrating and my partner isn't very supportive.