Ok, the title is a bit facetious, but after reading Freddd's reference to the Japanese study of intrathecal B12 injection for treatment of peripheral neuropathy in diabetics, I typed "B12 intrathecal" into Google and this came up: Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy. Ide H, Fujiya S, Asanuma Y, Tsuji M, Sakai H, Agishi Y. Abstract Seven men and four women with symptomatic diabetic neuropathy were treated with methylcobalamin (2,500 micrograms in 10 ml of saline) injected intrathecally. Treatment was begun when patients had good metabolic control, as determined by measurements of plasma glucose and hemoglobin, and was repeated several times with a one-month interval between injections. Three patients were re-treated one year after the last intrathecal injection. Symptoms in the legs, such as paresthesia, burning pains, and heaviness, dramatically improved. The effect appeared within a few hours to one week and lasted from several months to four years. The mean peroneal motor-nerve conduction velocity did not change significantly. The mean (+/- SD) concentration of methylcobalamin in spinal fluid was 114 +/- 32 pg/ml before intrathecal injection (n = 5) and 4,752 +/- 2,504 pg/ml one month after intrathecal methylcobalamin treatment (n = 11). Methylcobalamin caused no side effects with respect to subjective symptoms or characteristics of spinal fluid. These findings suggest that a high concentration of methylcobalamin in spinal fluid is highly effective and safe for treating the symptoms of diabetic neuropathy. I know it's a small study, but results were very positive with no side effects. Goes right along with what Freddd has been saying about CNS repair, doesn't it? And I heard they're now thinking that diabetes is the result of mitochondrial dysfunction - don't more than a few of us have mito. problems? So my question is, why aren't PWC's trying this? I don't have peripheral neuropathy but I have mondo brain fog and bad mental PEM. Maybe this would help. We should get Cheney going on this - he'd charge $11,000 per injection, but if it works and other docs do it, the price should drop to a couple hundred bucks, (sorry coudln't resist a bit of sarcasm - no offence meant to anyone ) Thoughts? PS Something that's intrigued me since I started reading Fredd's comments about CNS/CSF penetration is my experience with osteopathy. I went to 2 separates DO's and they both told me they couldn't detect the flow or rhythm of cerebral spinal fluid in me, (osteopaths claim to be able to feel or detect this flow and improve it if necessary with gentle manipulation - sounds a bit out there, but some sports concussion sufferers swear it has helped them). I wonder if this could be effecting me and again, if intrathecal injection of B12 could help?