Hello everyone, I'm de-lurking finally. I've got my 23andme results and with all of this brain fog cannot wrap my head around everything. I appreciate any assistance you may be able to give me in helping me figure this out before I begin communicating with my doc about it. Here goes: Detox (I'm only including Homozygous because Hetero are way too many to list) PON1 Q192R rs622 ++ CC IgE C3 rs366510 ++ GG FCER1A/OR10J2P rs2494262 ++ AA Methylation Homozygous AGT M235R/C4072T rs699 ++ GG CBS A360A rs1801181 ++ AA FUT2 rs492602 ++ GG FUT2 rs601338 ++ AA (yup, I'm immune to the Norovirus.) FUT2 rs602662 ++ AA GAD1 rs769407 ++ CC GAD1 rs3791851 ++ CC GAD1 rs3791878 ++ TT GAD1 rs701492 ++ TT GAD1 rs769395 ++ GG MTHFD1 C105T rs6362 ++ CC MTHFR 03 P39P ++ AA MTHFR A1298C ++ GG MTHFR A1572G ++GG MTHFR 6 more unnamed variants ++ MTHFS rs6495446 ++ CC PEMT rs4244593 ++TT TCN2 C766G rs1801198 ++ GG Heterozygous BHMT - all those listed on MTHFRSupport report COMT rs6269 +- COMT H62H rs 4633 +- COMT V158M rs4680 +- DAO rs2070586 +- DAO rs2111902 +- DHFR GAMT rs55776826 GIF (TCN3) +- MAO A R297R +- MTHFD1 G1958A +- MTHFD1L rs11754661 +- MTHFD1L rs6922269 +- (anyone notice this rs# is a palindrome?) MTHFR G1793A (R594Q) +- MTR A2756G +- MTRR A66G +- MTRR H595Y +- MTRR K350A +- MTRR rs10520873 MTRR rs9332 NOS2 - two of these are hetero on MTHFRSupport report NOS3 - two of these are hetero PEMT rs7946 +- SMHT2 rs34095989 +- SCL19A1 - both hetero VDR Bsm +- VDR Taq +- (I looked this one up in my raw data) Mitochondrial Function & Sulfonotransferase There are a handful of Homozygous and heterozygous mutations which I can post if you think they are relevant but my eyes are starting to cross just now. Besides the usual suspects, the ones that pop out at me to investigate further are PON1, PEMT, TCN2 and GIF(TCN3). What do you think? Thank you!