I've posted here before about whether to get the 23andMe test. I have in fact ordered the test & given my spit, so now I'm in the period of waiting 6 to 8 weeks before I get the results. This is after learning from the more readily available MTHFR test that I don't have either of the two most common gene mutations for metabolizing folate. Meanwhile I have a real problem with tingling in my hands and feet, and I'm wondering if the oral B12 I started taking about a month ago might be making it worse. As background, in 2007 I began experiencing pins-and-needles and tingling in my feet. An MRI and a nerve conduction study concluded that I have some spinal stenosis that is causing some compression in the nerve roots in my lumbar spine, thus causing a sort of static in the nerves. So the problem isn't really in my feet but in my back. Off and on in the years since, I've had episodes where sitting makes my symptoms worse. In November I started experiencing another such episode, which has gradually gotten worse. Right now, sitting is very difficult for me because the tingling gets worse even if I sit only a few minutes. And in the last couple of weeks the tingling has gotten worse in general, too - it's now more like burning than just tingling at this point. Worse yet, in the last few days I've noticed that the thumbs & forefingers of both hands are tingly too. As someone who's had fibromyalgia for 20-plus years, I'm familiar with tingling in my hands as something that comes and goes for no discernable cause . . . but now I'm thinking that I may have stenosis in my neck, too, with nerve compression showing up in my hands. So this new tingling may wind up being permanent. I'm going to talk to my doctor tomorrow about getting an updated MRI of both my back and neck to see what that shows. My other worry is that maybe I'm developing something systemic, like slow progressive MS. But what I want to ask is, could the large amount of oral B12 I'm taking be making things worse rather than better? I started it on Jan. 28, so that's about a month ago. I take 2,000 mcg of methyl-B12 (the Jarrow brand) and 5,000 mcg of dibencozide (the Source Naturals brand) each morning. Is that too much? I have read posts here that suggest taking small amounts, but usually that is only for people who find they react strongly to even small amounts of B12. I've never noticed an immediate reaction of any sort. I also take 800 mcg of the Soglar methylfolate per day, plus some other stuff like D3, magnesium, etc. None of this seems like it should have any influence. Probably the B12 isn't related at all to my symptoms . . . but if anyone sees a link or can suggest anything else for me to consider, I'd appreciate it.