I havent had OI that i noticed anyway for my year into this but since my recent PEM setback the OI has come on HARD. In a matter of 2 days i now can not stand for more than 30 seconds and if i do it takes about an hour for me to recover from it upon lying down. I have been in a drastic downhill slide for about a month since this last period of overexertion and its showing no signs of stopping even though im on bed rest 24/7. I just can not believe how quickly im deteriorating, i am now in need of a wheelchair immediatly. Is this something that can fluctiate with time or is it something i need to prepare to dig my heals in and learn a new way of life?