Well I am sure everyone knows how complex this is. I have been reading threads in this forum and wanted to get some input. It seems like some people lean more towards yasko, and others to their own studies (Valentijn). I would appreciate all and any ideas! Just to let you know what I am dealing with, blood test came back low normal B12 levels, and vitamin D level at 39. I bought sulfur test strips to test my urine in the morning and usually have levels over 1000, although when I take lithium orotate (Doctor's best), it oddly goes down to 600-800. Before I cut sulfur out of my diet, I was regularly getting 1600 levels, and I felt baaaaaad. Here are my results: Homozygous: BHMT-02 TT BHMT-04 CC BHMT-08 TT Heterozygous: COMT V158M AG COMT H62H CT VDR bsm CT VDR Taq AG MTHFR C677T AG MTRR A66G AG MTRR R415T CT CBS A360A AG I guess my biggest concern is the MTHFR, but to be honest there could be other implications that I do not know about. I really appreciate any help I can get. I think the work that the regulars do here is exemplary and I am grateful for this resource. Thanks!