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Can anyone help w 23andme results?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by ebethc, Jun 21, 2014.

  1. ebethc

    ebethc

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    Hi,

    I just got my 23andme results back, and I'm hoping that I can get some help prioritizing & interpreting the Genetic Genie output.

    My symptoms are brain fog, fatigue, joint pain / stiffness, IBS. I also get sick all the time and have a hard time recovering, which is I'm sure due to glutathione problems.

    +/+ METHYLATION RESULTS
    From what little I know at this point, I think this is the ranking:
    1. CBS C699T (worst)
    - I had a Glutathione/NAC/PC IV that made me REALLY sick. Probably due to sulphur, in hindsight. However, I take NAC & ALA with no problems. Same w eggs and other high sulphur foods. This sulphur thing is confusing.
    - I have sulfate test strips, and get 2 - 3 yellow/very light orange squares
    - I'm supposed to take Molybdenum 100 mcg, take 2 tabs HydroxyB12, low thiol diet, and do weekly Charcoal flushes, correct?
    2. BHMT 02 & 08
    - Taking sunflower lecithin 2.4 g... so far, so good
    3. MAO A
    - some say this is important, and some don't, but isn't this what's causing my cognitive problems?
    - not supposed to tx this one until I get results from the first two on this list correct?


    +/- METHYLATION RESULTS
    Should I just focus on CBS & BHMT for now? Which of these (if any) should I treat?
    1. COMT V158M & H62H
    2. VDR BSM & TAQ
    3. ACAT1-02
    4. MTRR A66G & K350A

    +/- DETOX RESULTS
    Nine yellows... I didn't see any reds, so I was happy :) Any thoughts on these results?

    The full profiles are attached. thanks!!

    Attached Files:

  2. Valentijn

    Valentijn Activity Level: 3

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    Amersfoort, Netherlands
    @ebethc - Your results don't seem to account for any problems. The CBS issues are a myth started by Yasko, based on an a rather staggering inability to read and interpret published research. If you feel fine with NAC, then it probably isn't a problem for you. Directly taking Glutathione, on the other hand, seems to cause problems for a lot of people.

    It's possible that your two MTRR mutations are causing a compound heterozygous problem, but I'm not sure if they're known to be capable of that. Additional MTRR and MTHFR SNPs you could look at are at http://forums.phoenixrising.me/index.php?threads/interesting-mtrr-variations.24551/ and http://forums.phoenixrising.me/index.php?threads/interesting-mthfr-variations.24543/ .

    http://sourceforge.net/projects/analyzemygenes/ is a program you can download which pulls out your rarest 23andMe results. Homozygous results and those starting with "i" instead of "rs" are usually the most interesting.
  3. ebethc

    ebethc

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    - I have a mac... I believe that program is windows?? I downloaded the program and it wasn't clear how to launch the program..

    thanks.
  4. Valentijn

    Valentijn Activity Level: 3

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    Amersfoort, Netherlands
    It might or might not work on a Mac, depending on how stupid the security is on your OS.

    The entire folder needs to be unzipped/extracted, (and your 23andMe downloaded file), then click on the file called "genes" to run it.
  5. PeterPositive

    PeterPositive Senior Member

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    It does work on Mac.
    Download, unzip, double click Genes.jar

    cheers
    ukxmrv and Valentijn like this.
  6. ebethc

    ebethc

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    Hi - trying to get some help again... Can anyone tell me which SNP(s) I should focus on first? I went to a naturopath who recommended starting w COMT & MAO, but I didn't notice a big difference w her protocol.

    thanks
  7. ebethc

    ebethc

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    I was unable to open this because the app store doesn't recognize the author..

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