Are there marked differences in the SPECT of the two? I'm in a difficult spot where I've had a couple tests here and there show positive Lyme but many more show negative. However, my brain symptoms are more severe than anyone I've seen with ME and only those with active Lyme in their brains rival mine. Also, my SPECT showed massive hypoperfusion yet I haven't had a doctor that knows very well how to interpret it past "oh my, I've never seen such widespread hypoperfusion" I'm wondering if the SPECT results could be a factor in a definitive diagnosis of one or the other. P.S. I'm not trying to say my suffering is worse than any others, just stating how severe my brain symptoms are.