I have done all my research and would love it if @Freddd @caledonia @Critterina could take a look at this. @Valentijn I would like some help with how to proceed. I do have a MTHFR doctor, but may be trying to find another, as mine has suggested some things that may indicate he isn’t as well versed as I would hope (suggesting for me to take ¼ of a 15mg Deplin and no b12 other than a minute amount in a non-sublingual non shot form ) – though I could be wrong. Oh boy…. here we go….. First off: I am a healthy person. I don’t have CFS/ME or any other problems. The only thing that is wrong with my OCD/anxiety/Depression. I have had it my whole life. I was on SSRI’s and other drugs prescribed to me by clueless doctors. They never really helped and made me so tired that I would fall asleep at stoplights. I got off them 1 year ago. I spent the whole year seeing tons of doctors and getting tons of blood work. The main reason for this was the fatigue. The fatigue went away after I got off the meds and improved some of my deficiencies (including getting my D from 11 to 60). I RADICALLY overhauled my diet. I used to eat primarily junk food and soda and crap. I now eat healthy, organic foods including lots of fruits and vegetables and just drink water. I have made tons of lifestyle changes. I eat Chinese and have some wine on the weekends but am good during the week. Avoid dairy and gluten as much as possible. PHYSICALLY I feel great. I spoke to Sherry Rogers over the summer and she had me taking folic acid every day after doing a phone consult with her after doing the MetaMetrix Cardio Ion panel. Later in the year a doc had me doing 1ml shots of methylcobalamin every week. I was feeling very sad/anxious/depressed in the fall. There was a lot of stuff that was happening in my personal life, coupled with “health anxiety”. I went to see a psychiatrist who wanted me on pristiq and deplin. I opted not to take the pristiq (proud of myself) b/c I didn’t want to start down the fatigue and side effect road again. I started taking the Deplin (15mg) after researching it online. I ran across someone talking about MTHFR. I remembered seeing MTHFR in my stacks of blood work (no doc ever mentioned – said nothing to worry about). Thus the journey began. I stopped taking the Deplin and ordered 23andme. I don’t THINK that I was having adverse reactions to the mehtylcobalamin or Deplin. I am not sure though. I had so many problems and anxiety around the time when I was taking it. Worst of my life. A lot of it was before I took any of them and the triggers to my episodes were the same whether I was on them or not. Here is where I am at. I am OCD/anxious. I start reading about MTHFR and I get really anxious. There is sooooo much information and conflicting information etc. I have literally had panic attacks after posting/reading Yasko’s board. After a year of spending hours a day and over 5000 on tests and doctors, I need a little break. I sometimes wonder if I would be better off not dealing with this as I feel 100 times better when I am not focusing on my health. I would like some recommendations on how to proceed. Please be aware that I am VERY sensitive to more and more tests and more and more supplements. For example: If you are going to take this then supplement with that and check this and then take this for that and check these levels and get these tests then supplement more. I want a simple plan. I can’t spend hours a day and thousands on more stuff. I need to get off this course. It has ruined my relationship and made me a crazy person. Still reading? Thank you. Here is where I am at. I am attaching all of my info. I have TONS of blood work. If anyone would like to see it or has any questions on anything that I might have tested, please let me know. I don’t know if there is anything that would be illuminating as far as future course of action. I do have high homocysteine (in range, but high?) I did have high methionine. I do have some aluminum. 1) People talk about cofactors and other things that you need to take – minerals, other b vitamins, etc. What is ESSENTIAL? 2) For my snps, what should I be taking? Which b12? Which methylfolate? Does any b12, give you the benefits? Do you just need to avoid b12’s that give you adverse effects? How much of each should I be taking and which should I start first? How quickly do I go up if I feel ok? 3) Once I start, I have niacin on hand and ordered potassium powder. How do I know if I need to take something and what to take and how much? 4) Are there any tests that I should take or info that anyone needs before I start this? 5) Will methylation fix anxiety/depression? My snps are in my signature. For ACAT, I think that my gut is fine. My NP says that I am absorbing (my K and B6 were through the roof after supplementing over the summer) I have regular bowel movements and rarely have diarrhea or upset stomach. I don’t have presence of yeast, celiac or major food allergies. CBS – heartfixer says that it results in slightly faster disposal of homocysteine and shouldn’t result in sulfur or ammonia problems. I also read that it lead to high levels of homocysteine. I did have high ammonia on a blood test and a doc retested it and it was down (didn’t do anything, just came down on its own.) I have been eating eggs every day and they don’t seem to bother me. I bought sulfate test strips. They are hard to read, but it seems that the reading changes throughout the day. Anywhere from 200 or 300 to 1000. The day after I drank wine they seemed to be high the whole day and came down the next day to 300/400 territory (again, hard to read). I am hetero, not homo, do I need to treat for this? Nutrachacker says to take B6 (I’m getting retested as I was high.) but I think I read that it shouldn’t be in p5p…is that correct? Am I ok to skip those two first priority mutations b/c my gut is “fine” and the strips are showing what they are? As for the rest of the treatment plan, there is a bunch of stuff I don’t understand from nutrahacker. Some thinks say to use a specific thing and others say to avoid. Do I basically need methylfolate and b12? Can I just take hydroxyl or adenosylcobalamin (do I need both?)? and methylfolate? A couple notes from my research: Since I have comt/vdr, I should be taking hydroxyl/adenosyl NOT methylcobalamin A lot of what Ive read says to avoid methyl donors. I assume l mehtylfolate is a methyl donor. How do you fix methylation without it? As far as MAO-A R297R - When a (+/+) MAO-A mutation is combined with a (+/+) or (+/-) COMT V158M mutation, imbalances in neurotransmitters may be more severe. These imbalances can potentially lead to neuropsychiatric conditions and symptoms such as Obsessive Compulsive Disorder (OCD), mood swings, and aggressive and/or violent behavior What about b4? DO I need to test for/supplement? I am attaching my 23andme, nutrahacker and detox Thank you in advance.