I've been treating myself for low stomach acid by taking betaine hcl + pepsin... it helps my chronic constipation.... big plus! 1. I take 2 caps twice a day... what is the best timing w regard to meals? I.e. X minutes before or after meals? 2. How does increasing stomach acid change histamine in stomach (if at all)? I'm asking because I believe ppl w mast cell issues (like me) supposedly have TOO MUCH acid... is this true? If there is a connection between stomach acid and histamine, then wouldn't adding more stomach acid via betaine/pepsin stimulate more histamine? I'm not far enough along in my betaine experiments to know exactly how it's affecting me beyond the positive effect on motility.. plus it's allergy season anyway 3. Some times I forget to take betaine so I take it between meals. I notice my head clears and I have less stiffness and pain after I take it.... it's subtle but distinct, and doesn't last more than an hour or less... can anyone explain the mechanism that drives this reaction?