In preparation for undergoing a methylation protocol, I stopped taking all supplements for about 2 weeks and have been slowly re-introducing them. I started adding cal/mag in small amounts and by the second day, started getting more late pm malaise. I had noticed this before with cal/mag. Didn't take it the next day and didn't get the late pm malaise, (I had taken it after lunch before). The magnesium is Natural Calm pure magnesium powder and the calcium is another powder, supposedly highly absorbable. So not sure what to do. How important is Cal/Mag to the active B12 supplementation? Don't suppose I could skip it? Input greatly appreciated.