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Bupropion and Inflammation

Discussion in 'Other Health News and Research' started by nanonug, Aug 12, 2012.

  1. nanonug

    nanonug Senior Member

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    Virginia, USA
    A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice.

    Abstract
    In a wide range of human diseases of inflammatory nature like Crohn's disease, pathology is mediated in part by pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF) or interferon-gamma. We show here that a commonly used generic antidepressant bupropion, in wide use worldwide to treat depression in humans for a decade now, profoundly lowers levels of TNF, interferon-gamma, and interleukin-1 beta in vivo, in a mouse lipopolysaccharide (LPS) induced inflammation model. Mice challenged with an otherwise lethal dose of LPS were protected by bupropion and levels of the anti-inflammatory cytokine interleukin-10 were increased. Previous data in rodents and humans indicate antidepressant effects of bupropion are mediated by its weak reuptake inhibition of norepinephrine and dopamine. Concordant with this, TNF suppression by bupropion in our mouse LPS model was largely abrogated by beta-adrenergic or dopamine D1 receptor antagonists but not by a D2 antagonist. TNF synthesis is controlled by an inverse relationship with intracellular cyclic adenosine monophosphate (cAMP) and stimulation of either beta-adrenoreceptors or D1 dopaminergic receptors result in increased cAMP but stimulation of D2 receptors lowers cAMP. We conclude that bupropion may suppress TNF synthesis by mediating increased signaling at beta-adrenoreceptors and D1 receptors, resulting in increased cAMP that inhibits TNF synthesis. Bupropion is well tolerated also in non-psychiatric populations and has less risk with long term use than current anti-inflammatory, immunosuppressive or TNF suppressive treatments such as prednisone, azathioprine, infliximab, or methotrexate. New anti-inflammatory treatments are needed. We believe a new chapter in antiinflammatory, TNF lowering treatment of disease has been opened. Bupropion's use for this in humans should be explored.
    Ema and Enid like this.
  2. Ema

    Ema Senior Member

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    I think this increasing of cAMP is going to be very important. And lowering interferon gamma.

    It turns out glucocorticoids (esp dexamethasone) also do this which may be another reason that steroids seem to help some people while also addressing low cortisol symptoms.

    I'm curious to know what dose of buproprion was used...I've got some here and I want to try.
  3. peggy-sue

    peggy-sue

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    That's "Welbutrin" isn't it? The one used for smoking stopping?

    It can have some pretty strange side-effects, I believe, in folk who are not depressed to start off with, I've heard some horror stories!

    But I have been seriously considering seeing about changing from citalopram to this, because it doesn't, apparently, have the same deleterous side effects on one's love life.
  4. Ema

    Ema Senior Member

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    Really? Yes, it is Wellbutrin.

    That article said it was well tolerated in non psych patients...but I'm sure it could be wrong. I guess I'll find out. I'm going to start on a very low dose.

    Now Chantix on the other hand, which is another anti smoking med, THAT I've heard some horror stories about.
  5. peggy-sue

    peggy-sue

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    Always best to start very low on anything anyway, Ema. :)

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