1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
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Nitric oxide and its possible implication in ME/CFS (Part 2 of 2)
Andrew Gladman explores the current and historic hypotheses relating to nitric oxide problems in ME/CFS. This second article in a 2-Part series puts nitric oxide under the microscope and explores what it is, what it does and why it is so frequently discussed in the world of ME/CFS....
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[Breakthrough] This could be the cure/treatment for Leaky Gut (PLoS ONE study)

Discussion in 'Other Health News and Research' started by Waverunner, Feb 23, 2012.

  1. cigana

    cigana Senior Member

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    Hi Waverunner. Isn't the answer in Maes' paper? I mean he showed that our current treatment options can both heal leaky gut (as measured by antibodies to LPS) and reduce/completely remove all CFS symptoms. Of course that didn't happen to all patients, so maybe those that were not helped (in terms of symptoms) would be helped by this new drug. It is not clear to me from Maes' paper, though, if those that didn't improve their symptoms had however healed their leaky gut...

    Thanks for posting this very exciting :)
  2. Waverunner

    Waverunner Senior Member

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    Yes, we probably will have to use trial and error to see if Linaclotide is a treatment option. However it is always better to have a variety of treatment options than just a few. Moreover this drug could be more efficient in treating increased intestinal permeability than supplements or other drugs. I just checked the average FDA approval times. Without Fast Track it seems to take about 12 months, so Linaclotide could be available in August/September 2012.
  3. SickOfSickness

    SickOfSickness Senior Member

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    I just found this thread. Exciting! Probably out in the next 6 months!

    And being used for IBS-C, relatively common, it may not be hard to get. Let's start saving our pennies so we can afford it ;) Seriously, I hope I can afford to seriously try it.

    I have suffered on and off with IBS but mine is IBS-D. I hope that this drug won't give me too bad side effects and could still work on my gut.

    The Xifaxan (Rifaxamin) testimonial is very interesting too.
  4. Waverunner

    Waverunner Senior Member

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    http://www.theflyonthewall.com/perm...expects-FDA-action-for-Aclidinium-Linaclotide

    Forest Labs expects FDA action for Aclidinium, Linaclotide
    NDA for Aclidinium was filed as planned in mid-2011, and the company expects FDA action in Q2. NDA for Linaclotide was filed in mid-2011, and the company also expects FDA action to come in Q2. Comments and guidance were taken from slides for the J.P. Morgan Annual Healthcare Conference. :theflyonthewall.com
  5. Athene

    Athene Never give up

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    Thanks for this relly exciting news Waverunner. I am really excited about this. I cannot wait to try this new drug!
    I think leaky gut contributes a huge amount to CFS symptoms, food intolerances and allergies in general, and the general feeling of illbeing. (I know that word doesn't really exist but it should).
  6. Waverunner

    Waverunner Senior Member

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    Hi Athene,

    I hope so much that you are right. If leaky gut plays an important role in our disease, this drug will help tremendously. If intestinal permeability however only plays a minor role...
  7. Waverunner

    Waverunner Senior Member

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