There are many people with ME/CFS who have LPS in their blood and the studies by Maes et al. all point into this direction. The question is whether our current treatment options reduce intestinal permeability (IP) so much that it does not contribute to CFS anymore. In this case there would be not much improvement through new drugs on improving gut integrity. On the other side however, if our current treatment options DO NOT improve IP enough, this could be a great treatment target.
Hi Waverunner. Isn't the answer in Maes' paper? I mean he showed that our current treatment options can both heal leaky gut (as measured by antibodies to LPS) and reduce/completely remove all CFS symptoms. Of course that didn't happen to all patients, so maybe those that were not helped (in terms of symptoms) would be helped by this new drug. It is not clear to me from Maes' paper, though, if those that didn't improve their symptoms had however healed their leaky gut...
Thanks for posting this very exciting