1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Nitric oxide and its possible implication in ME/CFS (Part 1 of 2)
Andrew Gladman explores the current and historic hypotheses relating to nitric oxide problems in ME/CFS. Part 1 of a 2-part series puts nitric oxide under the microscope and explores what it is, what it does and why it is so frequently discussed in the world of ME/CFS. Part 1 focuses...
Discuss the article on the Forums.

Breakthrough Research Reveals Pathway of Fibromyalgia

Discussion in 'Fibromyalgia' started by Gijs, Apr 20, 2013.

  1. Gijs

    Gijs Senior Member

    Messages:
    145
    Likes:
    141
    Posted: Thursday, April 18, 2013 7:44 am | Updated: 4:32 am, Fri Apr 19, 2013.
    By NAPS,
    North American Precis Syndicate

    (NAPSI)—For decades, debate has raged over whether fibromyalgia is a real medical disease. Despite the fact that fibromyalgia affects more than 12.3 million people in the United States—comparable to the number of people affected by cancer—some clinicians believe fibromyalgia is nothing more than a “syndrome.” When patients complain of chronic pain, diffuse muscle and joint tenderness, depression, mental fog, digestive troubles, severe fatigue, insomnia and other unbearable symptoms, they’ve often been told the problem is “in their heads.”
    Recently published breakthrough research conducted at the University of Illinois College of Medicine at Chicago should end the debate—and stigma faced by fibromyalgia patients—once and for all. These studies, comparing fibromyalgia patients to healthy people, confirm that fibromyalgia is an immune system disorder.

    The identification of this immune system pathway was not only honored with the 2012 American Association for Clinical Chemistry’s “Outstanding Research in Clinical and Diagnostic Immunology” award; it has also led to the first objective test capable of making a diagnosis of fibromyalgia.
    “What we discovered over years of research is that fibromyalgia patients have an abnormal immune system,” said Bruce S. Gillis, MD, MPH, lead researcher and founder of EpicGenetics. “These peer-reviewed results have finally been able to ‘tear back the curtain’ to reveal that fibromyalgia is an immune system dysregulation disease relating to the production of protein molecules called chemokines and cytokines by a certain type of white blood cell.”

    On average, fibromyalgia patients spend 3-5 painful years seeking a diagnosis, and $4,800-$9,300 annually on associated medical costs. By comparison, The FM Test, which costs $744, is a quick, simple blood test that offers conclusive results, usually in a week or less—a fraction of the time and money currently spent by patients seeking a diagnosis.

    Anyone with fibromyalgia symptoms can have his or her doctor order the test. Alternatively, patients may take a simple questionnaire at www.TheFMTest.com and utilize an FM Test physician to request a test. Those already diagnosed with fibromyalgia can take the test to confirm and establish a baseline that can be used to track treatment effectiveness.

    “The FM Test represents an objective biomarker that will prove useful in the diagnosis of an enigmatic disease,” said Ernest Brahn, MD, professor of medicine, Division of Rheumatology, at the UCLA School of Medicine

    http://www.exponent-telegram.com/on...cle_cb57f39b-f852-5367-88a1-ae786336cafd.html
     
  2. clive powney

    clive powney Senior Member

    Messages:
    175
    Likes:
    111
    coventry
    this looks like great news - my wife has already printed this off and is taking it to her specialist appointment next week. Are there any pointers to any drugs that may be useful ??
     
  3. maryb

    maryb iherb code TAK122

    Messages:
    2,920
    Likes:
    2,055
    UK
    This is really excellent news - Clive think the object of the research was just to find diagnostic markers which it looks like they've done. Fantastic really.
     
  4. Firestormm

    Firestormm Guest

    Messages:
    5,824
    Likes:
    5,982
    Cornwall England
    Unique immunologic patterns in fibromyalgia

    Frederick G Behm1, Igor M Gavin2, Oleksiy Karpenko2, Valerie Lindgren1, Sujata Gaitonde1, Peter A Gashkoff1 and Bruce S Gillis1*

    Abstract

    Background

    Fibromyalgia (FM) is a clinical syndrome characterized by chronic pain and allodynia. The diagnosis of FM has been one of exclusion as a test to confirm the diagnosis is lacking. Recent data highlight the role of the immune system in FM. Aberrant expressions of immune mediators, such as cytokines, have been linked to the pathogenesis and traits of FM. We therefore determined whether cytokine production by immune cells is altered in FM patients by comparing the cellular responses to mitogenic activators of stimulated blood mononuclear cells of a large number of patients with FM to those of healthy matched individuals.
    Methods

    Plasma and peripheral blood mononuclear cells (PBMC) were collected from 110 patients with the clinical diagnosis of FM and 91 healthy donors. Parallel samples of PBMC were cultured overnight in medium alone or in the presence of mitogenic activators; PHA or PMA in combination with ionomycin. The cytokine concentrations of IFN-γ, IL-5, IL-6, IL-8, IL-10, MIP-1β , MCP-1, and MIP1-α in plasma as well as in cultured supernatants were determined using a multiplex immunoassay using bead array technology.
    Results

    Cytokine levels of stimulated PBMC cultures of healthy control subjects were significantly increased as compared to matched non-stimulated PBMC cultures. In contrast, the concentrations of most cytokines were lower in stimulated samples from patients with FM compared to controls. The decreases of cytokine concentrations in patients samples ranged from 1.5-fold for MIP-1β to 10.2-fold for IL-6 in PHA challenges. In PMA challenges, we observed 1.8 to 4-fold decreases in the concentrations of cytokines in patient samples.
    Conclusion

    The cytokine responses to mitogenic activators of PBMC isolated from patients with FM were significantly lower than those of healthy individuals, implying that cell-mediated immunity is impaired in FM patients. This novel cytokine assay reveals unique and valuable immunologic traits, which, when combined with clinical patterns, can offer a diagnostic methodology in FM.


    Greetings :) I can't comment on the actual test that is being marketed and that is I notice trademarked; but thought you might like to read the research behind it all at least.
     
    taniaaust1, WillowJ, MeSci and 2 others like this.
  5. alex3619

    alex3619 Senior Member

    Messages:
    7,688
    Likes:
    12,535
    Logan, Queensland, Australia
    This idea of testing samples under stress in isolation is paying dividends. It worked in OI, it worked in FMS and I vaguely recall it was used somewhere else, though it might have been an early release of the FM data that I am misrecalling. Finding the cells, isolating them, then challenging them and comparing that to controls gives you an assay if there is a significant difference. This is really good news for many millions of FM patients, especially if they are being diagnosed under psychogenic diagnoses and need to fight it, or are struggling to be recognized for insurance or benefits.
     
    MeSci, WillowJ and Sasha like this.
  6. clive powney

    clive powney Senior Member

    Messages:
    175
    Likes:
    111
    coventry
    Hi maryb, I (hopefully)understand the overall outcome of this, but the missus hasnt had a proper diagnosis yet and the specialists keep changing their minds between FM , RA and AS. I also know from my experiences in the UK the NHS are very blinkered for some reason and many of the doctors seem to think they know everything in their field and become very arrogant and dismissive of cutting edge research from elsewhere. So it is an opportunity to maybe open at least one specialists eyes. He might at least look into it, I certainly would if I were in his position.
     
    MeSci likes this.
  7. Marco

    Marco Old blackguard

    Messages:
    1,386
    Likes:
    1,064
    Near Cognac, France
    I'm not intending to dismissive but this reads to me more like an EpicGenetics press release.

    Surely if a biomarker for fibromyalgia had been validated and accepted it would have been really big news given the 12 million Americans affected and the still commonly held opinion that its another 'medically unexplained' syndrome.

    Unless I've missed the press coverage elsewhere?
     
    Valentijn likes this.
  8. Firestormm

    Firestormm Guest

    Messages:
    5,824
    Likes:
    5,982
    Cornwall England
    Hence my 'no comment' about the 'test' itself, Marco. Who knows how effective it really is? There is little information about it or whether it has been validated independently. The research is interesting, but the market is overflowing it often seems with commercial tests. Then I am ever a cynical buggar :)
     
  9. maryb

    maryb iherb code TAK122

    Messages:
    2,920
    Likes:
    2,055
    UK
    clive powney
    I know the feeling Clive:( I hope he will look at it , anything that actually gets them to think is good.
    I know the problem with the UK is you sometimes get to see an inexperienced doctor when you need to see a really experienced person, and then sometimes even the consultants are crap - luck of the draw. Arrogant and dismissive definitely.
    I just dropped lucky in that I got a rheumatologist, he was old school - actually now retired - to confirm fibromyalgia, funnily enough I saw an orthopeodic surgeon recently who was looking at my back, bye the bye he said, obviously fibromyaligia too....
    But to get 3 different diagnosis is hard on anyone - I mean what is so difficult??
     
  10. Marco

    Marco Old blackguard

    Messages:
    1,386
    Likes:
    1,064
    Near Cognac, France
    Not only am I also a cynical bugger - I'm also pragmatic enough to know that if I take an unvalidated (not to mention not FDA or NICE sanctioned) test result to a GP it'll be treated with the same respect as a Holland and Barrett food 'allergy' test.
     
  11. ukxmrv

    ukxmrv Senior Member

    Messages:
    3,530
    Likes:
    2,081
    London
    A UK GP would be hard pressed to even understand what this means. I've taken immune system results to GP's and even to consultants and they are so badly behind immune system advances that they were unable to read or appreciate what they were.

    NHS labs just don't test for these things. I tried through my local PCT and the only immune function they could offer was a CD4 count to their HIV patients. That's in London where we have an abundence of hospitals.

    <snip from article above>
    Cytokine levels of stimulated PBMC cultures of healthy control subjects were significantly increased as compared to matched non-stimulated PBMC cultures. In contrast, the concentrations of most cytokines were lower in stimulated samples from patients with FM compared to controls. The decreases of cytokine concentrations in patients samples ranged from 1.5-fold for MIP-1β to 10.2-fold for IL-6 in PHA challenges. In PMA challenges, we observed 1.8 to 4-fold decreases in the concentrations of cytokines in patient samples.
     
  12. MeSci

    MeSci ME/CFS since 1995; activity level 6

    Messages:
    3,831
    Likes:
    4,592
    Cornwall, UK
    Doctors I have seen have often been unable to interpret the results even of tests they have ordered themselves. Then attempts to get copies of the results so that I can analyse them myself have been met with hostility, bewilderment and obstruction. I was even referred to a hospital's legal department when trying to obtain them!
     
    PhoenixDown likes this.
  13. Valentijn

    Valentijn Activity Level: 3

    Messages:
    6,692
    Likes:
    10,142
    Amersfoort, Netherlands
    Yes, the biomarker claim sounds like a giant pile of BS. My guess is that someone ran a study testing a bunch of substances, and found some abnormalities for the FM patients. There are hundreds, if not thousands of studies which have done this for FM and ME/CFS.

    But then some genius decided to call these abnormal results a biomarker, even though there's probably dozens of other studies which partially contradict the current results. And, of course, I doubt they bothered to see if the abnormal results they found in FM patients are similar to the abnormal results in any other diseases, meaning there's no guarantee that being positive for FM looks any different than being positive for RA, etc.

    Useful research maybe, but they are grossly over-hyping it.
     
    ukxmrv likes this.
  14. taniaaust1

    taniaaust1

    Messages:
    8,241
    Likes:
    5,209
    Sth Australia
    FM thou has as poor of coverage as ME/CFS gets. Any big breakthrous could take a while before getting any media attention. Being new research thou.. its not going to be accepted etc for a while.
     
  15. baccarat

    baccarat Senior Member

    Messages:
    188
    Likes:
    80
  16. Esther12

    Esther12 Senior Member

    Messages:
    5,383
    Likes:
    5,884
    Ta. Browsing off PC, so cannot type much, but I spent some time browsing that blog. I don't know much about FM's.
     
  17. SickOfSickness

    SickOfSickness Senior Member

    Messages:
    1,881
    Likes:
    961
    US
    I got excited about this for a minute :(
     
    Enid likes this.
  18. PhoenixDown

    PhoenixDown Senior Member

    Messages:
    258
    Likes:
    235
    UK
    I agree with Marco in that it's difficult to get establishment to acknowledge the meaning and validity of these tests, and until we do, they may not be of much use. It depends on how supportive your family and friends are to begin with, they could either stand by you and accept that tests like these demonstrate objective abnormalities which require special consideration or they can side with the majority of the medical establishment (no matter how obviously flawed their logic is) and say it's a will power thing, part of the human condition, or entirely imaginary.
     
  19. PhoenixDown

    PhoenixDown Senior Member

    Messages:
    258
    Likes:
    235
    UK
    Just found this:

    Interesting, IL-5 concentrations were shown to be decreased in Unique immunologic patterns in fibromyalgia. , but given some of my allergy symptoms one would think the opposite is true. So I'm quite curious now. It depends exactly where you find the cytokines I suppose.
     

See more popular forum discussions.

Share This Page