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BREAKTHROUGH: New Spinal Fluid Analysis Distinguishes Lyme from CFS

Discussion in 'Latest ME/CFS Research' started by eric_s, Feb 23, 2011.

  1. eric_s

    eric_s Senior Member

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    http://www.prohealth.com/library/showarticle.cfm?libid=15959

     
  2. eric_s

    eric_s Senior Member

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    The dentists... :eek::angel: Now we might know why they were appointed to the SEP...
     
  3. eric_s

    eric_s Senior Member

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    This is bye bye to the name CFS i guess. If this finding is confirmed it can be only a matter of time for a more appropriate name. Or don't you think?
     
  4. Merry

    Merry Senior Member

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    I was happy to see this. Thank you, eric_s.
     
  5. urbantravels

    urbantravels disjecta membra

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    Here's the press release from the University (no dentists involved in this research; it's just part of the name of the university)

    http://www.umdnj.edu/cgi-bin/cgiwra...sh Lyme Disease from Chronic Fatigue Syndrome

    A report from the New Jersey Star-Ledger:

    http://www.nj.com/news/index.ssf/2011/02/umdnj_report_identifies_protei.html

    Amy Dockser Marcus at wsj.com:

    http://blogs.wsj.com/health/2011/02...drome-and-lyme-disease/?mod=google_news_blog#

    See my comment, the first, in response to Suzanne Vernon: POKE MY SPINE, PLEASE!!!
     
  6. eric_s

    eric_s Senior Member

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    Here's the paper:

    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017287

    Steven E. Schutzer1#*, Thomas E. Angel4#, Tao Liu4#, Athena A. Schepmoes4, Therese R. Clauss4, Joshua N. Adkins4, David G. Camp II4, Bart K. Holland3, Jonas Bergquist5, Patricia K. Coyle6, Richard D. Smith4, Brian A. Fallon7, Benjamin H. Natelson2,8

    1 Department of Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America, 2 Department of Neurology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America, 3 Division of Biostatistics and Epidemiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America, 4 Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America, 5 Department of Physical and Analytical Chemistry, Uppsala University, Uppsala, Sweden, 6 Department of Neurology, State University of New York-Stony Brook, Stony Brook, New York, United States of America, 7 Department of Psychiatry, Columbia University Medical Center, New York, New York, United States of America, 8 Department of Pain Medicine and Palliative Care and Beth Israel Medical Center, Albert Einstein School of Medicine, Bronx, New York, United States of America



    Abstract

    Background

    Neurologic Post Treatment Lyme disease (nPTLS) and Chronic Fatigue (CFS) are syndromes of unknown etiology. They share features of fatigue and cognitive dysfunction, making it difficult to differentiate them. Unresolved is whether nPTLS is a subset of CFS.


    Methods and Principal Findings

    Pooled cerebrospinal fluid (CSF) samples from nPTLS patients, CFS patients, and healthy volunteers were comprehensively analyzed using high-resolution mass spectrometry (MS), coupled with immunoaffinity depletion methods to reduce protein-masking by abundant proteins. Individual patient and healthy control CSF samples were analyzed directly employing a MS-based label-free quantitative proteomics approach. We found that both groups, and individuals within the groups, could be distinguished from each other and normals based on their specific CSF proteins (p<0.01). CFS (n = 43) had 2,783 non-redundant proteins, nPTLS (n = 25) contained 2,768 proteins, and healthy normals had 2,630 proteins. Preliminary pathway analysis demonstrated that the data could be useful for hypothesis generation on the pathogenetic mechanisms underlying these two related syndromes.


    Conclusions

    nPTLS and CFS have distinguishing CSF protein complements. Each condition has a number of CSF proteins that can be useful in providing candidates for future validation studies and insights on the respective mechanisms of pathogenesis. Distinguishing nPTLS and CFS permits more focused study of each condition, and can lead to novel diagnostics and therapeutic interventions.



    Citation: Schutzer SE, Angel TE, Liu T, Schepmoes AA, Clauss TR, et al. (2011) Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome. PLoS ONE 6(2): e17287. doi:10.1371/journal.pone.0017287

    Editor: Howard Gendelman, University of Nebraska, United States of America


    Received: November 29, 2010; Accepted: January 26, 2011; Published: February 23, 2011

    Copyright: 2011 Schutzer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    Funding: National Institutes of Health, through NIAID (grant AI088765), NIDA (grant DA021071), NINDS (grant NS38636), the National Center for Research Resources (RR018522), the Swedish Research Council (621-2008-3592), Uppsala Berzelii Technology Center for Neurodiagnostics, SciLifeLab-Uppsala, Time for Lyme, Lyme Disease Association, and the Tami Fund for support of portions of the research. Pacific Northwest National Laboratory units are located in the Environmental Molecular Sciences Laboratory, a national scientific user facility, sponsored by the Department of Energy (DOE), operated by Battelle Memorial Institute for the DOE under Contract DE-AC05-76RL0 1830. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

    Competing interests: The authors have declared that no competing interests exist.

    * E-mail: schutzer@umdnj.edu

    # These authors contributed equally to this work.
     
  7. eric_s

    eric_s Senior Member

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    This sounds impressive... p<0.01...
     
  8. max

    max *****

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    nice one eric_s

    :thumbsup:
     
  9. eric_s

    eric_s Senior Member

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    Poor PACE trial study... didn't have a long life :D This is my quick prediction after reading this...
     
  10. George

    George waitin' fer rabbits

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    Hey if a headache inducing, pain creating, muscle cramping spinal tap will get me a correct diagnosis and even the hint of possible treatments. . . . Where do I sign up??? (grins) I don't know about Dr. Vernon but I'm so sick that a spinal tap is no worse than grocery shopping for me so I'd sign up in a heart beat. (just give me a nice bone to bite when they stick the needle in!)

    Now here's a silly question. . . so where did all those unique proteins come from? anyone, anyone, Buller? I mean could viruses cause all those proteins? Or maybe a retrovirus that produces proteins? Or oh, no don't tell me it's the fact that I'm wearing my false illness belief corset,(Well UT said she didn't want it any more, grins) that caused all those weird proteins?
     
  11. CBS

    CBS Senior Member

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    And while I longer look good in it, I've so desperately clung to mine as emotionally, I need it (the self delusional notion that it was flattering) more than I need to rejoin society as that would require I confront my fears and initiate the hard work of searching my sole in order to regain my health. Yet, if I were to resume my role as a contributing member of society I may no longer need the constraint I find impossible to resist.

    Please someone get me Peter White's phone number before this epiphany fades! :victory:
     
  12. Esther12

    Esther12 Senior Member

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  13. George

    George waitin' fer rabbits

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    (SNORT!) And your corset goes so well with your biker bandana and leather coat. Most people don't know that your little kid pic is sitting on a harley. (grins) I have to say the pink lace's are a great contrast with the black leather. Man you could start a trend amoung the Wessly, White and Chalder gang. (Snort!)
     
  14. urbantravels

    urbantravels disjecta membra

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    OK, I'm just going to try to clear the image of CBS in a corset from my mind long enough to focus my mind on the actual question, and quote once again from the CAA report on the paper:

    my emphasis...

    Googling "complement cascade" quickly got me in over my head, but it appears to be a chain reaction of different immune system proteins that goes along several different pathways to try and kill pathogens. There are cytokines in there, by the way..

    My only-slightly-educated guess is that having these proteins elevated could possibly either mean the body is trying to fight a chronic infection(s), or it could mean the immune system is activated for some other reason. Neither of which would be surprising new hypotheses about the cause of ME/CFS.

    I can't help wondering which of these proteins might match up with elevated cytokines per the Lights' research.
     
  15. ahimsa

    ahimsa Senior Member

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  16. August59

    August59 Daughters High School Graduation

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  17. Enid

    Enid Senior Member

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    Like a "hole in one" to me eric. Never doubted ME should have been investigated more at "spinal tap" stage - mine showing abnormalities there and in the brain which were never pursued.
     
  18. SilverbladeTE

    SilverbladeTE Senior Member

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    Hey Wessely, Sharpe etc, EAT CROW!!! :p

    and no that's not some bizzare threat, anyone but a retard would know that's reffering to being "made ot eat humble pie" after being arrogant and rotten to people. Smiley, this thing ":p" indicates humour/sarcasm and/or satire.
     
  19. eric_s

    eric_s Senior Member

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    I didn't know this! And this was not investigated instantaneously, research projects funded, doctors educated?!?! What the hell is wrong with the people in those positions? I have not read the Baraniuk and Sorensen papers yet, but how could anyone still doubt ME/CFS is real and physical after those, if they found a statistically significant difference?

    Edit: Those studies were published in 2003, 2005 and 2009 and i have not heard one doctor tell me about it!!! Seriously! Are they actually good for anything (the doctors)?
     
  20. Enid

    Enid Senior Member

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    Quite eric - 10 years ago left a major UK Neurology Unit (well speechless and had to be escorted/driven everywhere) after my lumbar puncture showing brain "high spots" and spinal column abnormalties. Rapid decline followed (all ME problems) from which never fully recovered. My own guess "high spots" something to do with "tangling" due to the presence of abnormal proteins. For nothing was diagnosed.
     

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