It would be easy to get the impression that they effectively used Fukuda, but they didn't. Ref 23 is the Reeves 'Empiric' criteria. The Empiric criteria is, in fact, based on Fukuda - hence the same exclusions, medical history etc - but the 'empiric' bit refers to thresholds for fatigue, physical function etc - and that's where the empiric gets it wrong. See above re PACE - the PACE figures are in line with other outpatient studies as far as I recall - maybe a bit higher. The as yet unpublished muscle culture work done by Newton's group, using muscle biopsy samples from the same patients found similar problems and acidosis - oxygenation would be the same in both controls and patients in muscle culture, suggesting the problem is not oxygenation itself (They think it's a problem with the cell metabolism, which means not enough glucose gets burned in mitochondria).