New era for ME/CFS research as top cytokine study attracts media headlines
The immune systems of patients who have recently developed ME/CFS look markedly different from those who have been ill for much longer, according to a major new study from Drs. Ian Lipkin and Mady Hornig at Columbia University. This shift in immune function hadn’t been seen before.
Discuss the article on the Forums.

Brain damage/dysfunction and substances that give near remission

Discussion in 'General ME/CFS Discussion' started by knackers323, Nov 12, 2013.

  1. Tristen

    Tristen Senior Member

    Messages:
    620
    Likes:
    440
    Northern Ca. USA

    Thanks Dufresne, I am interested in your online source. Have a link? Appreciate the advice on the use and discontinuance of Baclofen....I wasn't aware of that. Even though I'm not the wired/tired type, I may still give it a go. Baclofen is fairly benign compared to many other things I've tried.

    Even though these drugs are more about treating symptoms rather than the cause of our disease......so what, as long as they are effective and don't compound the problem. The majority of treatable diseases today are only treating and controlling symptoms, rather than a cure. Anything to escape the horrible symptoms of me/cfs, that is safe and somewhat effective, is ok with me. I want as much of my life back as possible. Cheers everyone.
     
  2. knackers323

    knackers323 Senior Member

    Messages:
    893
    Likes:
    184
    Hi can you tell me a bit more about gaba and glutamate in cfs please. I have not heard of this
     
  3. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,622
    Likes:
    5,263
    australia (brisbane)
    excess NMDA is also in the mix with this.

    wow Dufresne thats some big doses of baclofen.
    I have used up to 75mg but now settle for 25mg as for me i didnt find any increase in effect from the higher dose. I didnt use baclofen all the time but intermittently to help sleep which it did help improve sleep quality when i used it with other sleep meds. Outside of better sleep which also improves function, i didnt really notice any other effects.

    info i found on baclofen said it helped increase growth hormone probably by increase sleep quality and deep stage 3/4 sleep. it was said to be the poor mans version of xyrem.

    Said to work on gaba B receptors similar to xyrem and the supplement phenibut. traditional benzo sleep meds work on gaba A receptors. Its indicated as a muscle relaxer but i didnt find it helped with that either, just improved sleep quality. I also read that there was no tolerance to it which isnt the case which is why i end up using it intermittently.

    cheers!!
     
    Little Bluestem likes this.
  4. Dufresne

    Dufresne almost there...

    Messages:
    435
    Likes:
    343
    Baclofen does little for me at smaller doses. I don't find it functions as a sedative in the slightest, more like an antidepressant. I take pleasure in all my daily chores now. It makes me feel useful and motivated. GHB is so much more sedating. Perhaps a good strategy for those with sleep problems would be to take fairly large doses of baclofen throughout the day and then switch to GHB for sleep.

    The increase in growth hormone is common to all GABA B receptor agonists, and they are significant. It's said that GH is the key to other hormones. This might be beneficial to us. My libido is tripled on the drug. I'm noticing the hip to waist ratio on all the nubile women I come across.
     
    Last edited: Nov 16, 2014
    heapsreal likes this.
  5. knackers323

    knackers323 Senior Member

    Messages:
    893
    Likes:
    184
    Has anyone had any more progress with the opiates or similar?
     
  6. Hip

    Hip Senior Member

    Messages:
    3,643
    Likes:
    3,737
    When you say you have to go big with baclofen, what sort of dose are you talking about?

    Myself I have not taken more than 20 mg of baclofen. Do you think this might be too little to get any effects?
     
    Little Bluestem likes this.
  7. Tristen

    Tristen Senior Member

    Messages:
    620
    Likes:
    440
    Northern Ca. USA

    I remain looking for the best option. Currently take max dose of Tramadol (300mg/day) which gives me a little relief, maybe 25% of what I would get with narcotics such as Hydrocodone......but a little is better than nothing, and I don't want to take narcotics. Soon I'm gonna try the Butrans patch. It's the same drugs as found in Suboxone, but is a slow release and therefore should get away from the narcotic effect....I hope. Suboxone does give me relief.....but I can't get that since it's primarily used for drug addiction/withdrawl.
     
  8. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,622
    Likes:
    5,263
    australia (brisbane)
    I mostly use tramadol 200mg sr for pain, mostly lower back and of late my neck has gotten worse. As my doc said my spine seems alot older then me, with alot of bone spurrs etc etc Anyway i felt like the tramadol wasnt working, probably a tolerance so my doc had me on kapanol which is a slow release morphine, this was just for a few weeks and then back to tramadol and hoping my tolerance to it has dropped, which it seemed too. What i found comparing the effects of tramadol to kapanol (disreguarding the tolerance issues) i think the tramadol for me works much better. It feels like it has an energizing effects and better pain relief effects compared to kapanol??

    so thats my experience with tramadol vs narcotic/morphine/kapanol?? i suppose we are all different.
     

See more popular forum discussions.

Share This Page