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BPS model redundant in IBS

Discussion in 'Other Health News and Research' started by Demepivo, Jul 1, 2017.

  1. Demepivo

    Demepivo Dolores Abernathy

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    Interesting spot by @Keith Geraghty in the New England Journal of Medicine. Looks at change from BPS model to physiological one. Looking at infection, inflammation, gut biome & nervous system

    http://www.nejm.org/doi/full/10.1056/NEJMra1607547

    Irritable Bowel Syndrome
    Alexander C. Ford, M.D., Brian E. Lacy, M.D., and Nicholas J. Talley, M.D., Ph.D.

    N Engl J Med 2017; 376:2566-2578June 29, 2017DOI: 10.1056/NEJMra1607547

    SOURCE INFORMATION
    From the Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, and the Leeds Gastroenterology Institute, St. James’s University Hospital, Leeds, United Kingdom (A.C.F.); the Section of Gastroenterology and Hepatology, Dartmouth–Hitchcock Medical Center, Lebanon, NH (B.E.L.); the Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW, Australia (N.J.T.); the Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (N.J.T.); and Karolinska Institute, Stockholm (N.J.T.).

    Old BPS model

    Old BPS model.JPG

    Newer physiological one

    Newer physiological one.JPG

    The full paper is available from Sci Hub

    https://sci-hub.cc/10.1056/NEJMra1607547
     
    Last edited: Jul 1, 2017
  2. Demepivo

    Demepivo Dolores Abernathy

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  3. MEMum

    MEMum Senior Member

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    Excellent
     
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  4. A.B.

    A.B. Senior Member

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    Edit: nevermind, I was looking at the "old BPS model" and didn't realize it.
     
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  5. Demepivo

    Demepivo Dolores Abernathy

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  6. dangermouse

    dangermouse Senior Member

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    Now that is very interesting :thumbsup:
     
  7. ljimbo423

    ljimbo423 Senior Member

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    Interesting thread! I did a search and couldn't find this study posted. It found exhausted T cells in IBS.

    link
     
  8. frederic83

    frederic83 Senior Member

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    France
    A real scientific model. I like that.
     
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  9. dangermouse

    dangermouse Senior Member

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    A refreshing change, I'd almost forgotten what it felt like!
     
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  10. Demepivo

    Demepivo Dolores Abernathy

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    There are similar models to this IBS one are being developed by Mady Horning & Flute & Mella for ME.

    Infection, inflammation, gut biome, nervous system, the brain... It's incredibly complicated piecing everything together but the links are slowly coming together.

    I guess scientists are working on similar models across the range of autoimmune & inflammatory conditions.

    It's all there in the scientist literature.... It's Saturday evening, so leave it until Monday.... Have a beer if you can tolerate it :)
     
  11. dangermouse

    dangermouse Senior Member

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  12. ljimbo423

    ljimbo423 Senior Member

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    This is really good news! I'm very much looking forward to more researchers making "the connections"!
     
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  13. Londinium

    Londinium Senior Member

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    Good to see this getting play in a high-impact journal as well. At some point, surely, The Lancet is going to start feeling lonely...
     

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