The 12th Invest in ME Research Conference June, 2017, Part 2
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Both slow and fast liver phase 1 possible?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by jason30, Nov 20, 2015.

  1. jason30

    jason30 Senior Member

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    Hi all,

    I am having problems with detoxing and I am trying to determine what my liver phase 1 and 2 status are.

    I have Multiple Chemical Sensitivities, what means that I have a fast phase 1 and slow phase 2, says the theory.
    However, I am also sensitive to caffeine, slow caffeine clearance, which is a direct symptom of a slow phase 1.

    In order to threat my liver problems I try to figure out if I have a slow or fast phase 1. Does anybody know if there can be both (unlikely though!) ? Or have more information about determine the status of phase 1 and 2 of the liver?

    Thanks in advance for any help on this subject!
     
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  2. Gingergrrl

    Gingergrrl Senior Member

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    @jason30 I am of no help but am very curious on this topic and bumping up the post hoping someone else responds. I am also (now) intolerant of caffeine and have slow liver detox which affects the dosages and amounts of meds that I take. But am still an amateur at understanding this and how to work with it!
     
  3. Little Bluestem

    Little Bluestem All Good Things Must Come to an End

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    I have no knowledge on the subject, but am wondering if you could have a phase 1 slow enough to cause slow caffeine clearance and an even slower phase 2 to cause multiple chemical sensitivities.
     
  4. sregan

    sregan Senior Member

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    Grapefruit is supposed to slow down phase 1 detox (see link)
     
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  5. Helen

    Helen Senior Member

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    Does it? That would be interesting to read more about. Do you have a source.

    Different CYP´s or SNP´s mean upregulation OR downregulation according to how they act on enzyme production. I can´t see how the sum of enzyme production from CYP´s in Phase I could be both slow and fast at the same time. Maybe certain food, or substances , could up- or downregulate certain CYP´s as much as to change from fast to slow or reverse for the total Phase I detoxification.
     
  6. jason30

    jason30 Senior Member

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    In the past 2 years that's the only thing I have read about it; a fast phase 1 and slow phase 2 indicating MCS. Though all sources doesn't have any references to researches.

    2 sources:

     
  7. jason30

    jason30 Senior Member

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    Good to know, thanks!
     
  8. jason30

    jason30 Senior Member

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    I don't know if that's possible, but in theory it could be the case by me as well!

    Soon I will start with foods and supplements that inhibit phase 1 and stimulate phase 2. I'm very curious how I will react.
     
  9. Gondwanaland

    Gondwanaland Senior Member

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    For a long time I thought I had fast phase I and slow phase II, and slowing down phase I was the worst thing I ever went thru (I used Nicotinamide, Boswellia).
     

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