1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Knitting Equals Pleasure, Despite ME/CFS
Jody Smith loves knitting. Again. She thought her days of knitting and purling were long over but ... she's back ...
Discuss the article on the Forums.

Borrelia IgG 1:400 (positive)

Discussion in 'Lyme Disease and Co-Infections' started by Thinktank, Sep 22, 2013.

  1. Thinktank

    Thinktank Senior Member

    Messages:
    402
    Likes:
    209
    Europe + South East Asia
    So, just got the results back from an ELISA test on IgM and IgG against Borrelia.
    IgM came back negative but IgG is 1:400 (positive).

    Can one have lyme's disease with negative IgM and positive IgG?
    The doc. says it shows a past exposure but i'm currently not infected, i believe that's bull so i want further testing to be done. What's considered as the golden-standard for lyme's testing?
     
  2. cigana

    cigana Senior Member

    Messages:
    643
    Likes:
    235
    UK
    There is no real gold standard, that's the problem. It's best to make a clinical diagnosis.
    However, you can also simply keep trying PCR periodically, check which bands you get on a western blot and see if any are specific to lyme. Antiobiotic challenges are useful too, to bring the borrelia out of hiding and into the bloodstream.
    But I would go for the clinical diagnosis with a good lyme doc.
     
  3. Thinktank

    Thinktank Senior Member

    Messages:
    402
    Likes:
    209
    Europe + South East Asia
    cigana, i have to be in Belgium and Germany next month and will do all testing for lyme and co-infections with infectolab and redlabs. KDM is a pretty good lyme-literate doc. if i have to believe so, looking forward to what he will have to say.

    After doing some reading on IgG and IgM i found out that a positive IgG and negative IgM is indicative of late stage lyme disease.

    I'm not a big fan of abx now i know how important our microbiome is, but it looks like it's the only way to eradicate that bug.
     
    Ema likes this.
  4. cigana

    cigana Senior Member

    Messages:
    643
    Likes:
    235
    UK
    KDM only uses abx that are targetted to the infection, not broad spectrum that wipe out large swathes of the microbiome. He combines abx with probiotics to help with this problem. He has done much research on the gut and CFS so he knows the effect of what he is doing, but has calculated that the risk is worth it. Of course there is always risk though.
     
    SOC likes this.
  5. SickOfSickness

    SickOfSickness Senior Member

    Messages:
    1,872
    Likes:
    954
    US
    I believe Dr Jamie. She and her daughter took abx for years, and she was a supporter of ILADS and now she is against them. She discussed reasons a bunch of times on her blog. http://www.x-rx.net/blog
     
    roxie60 likes this.
  6. cigana

    cigana Senior Member

    Messages:
    643
    Likes:
    235
    UK
    Hi SOC (I mean SickOfSickness :) ),
    Do you know where the posts are that discuss her reasons for taking abx and how much they helped?
     
  7. SickOfSickness

    SickOfSickness Senior Member

    Messages:
    1,872
    Likes:
    954
    US
    Well she is down on antibiotics for lyme now. She disagrees with that. I believe she stopped at least 3 years ago? I don't know if she has early posts being pro-antibiotics or not.

    SOC is someone else, by the way. It's a common mistake.
     
  8. cigana

    cigana Senior Member

    Messages:
    643
    Likes:
    235
    UK
    doh :)

    I find it strange that someone can respond to antibiotics and then consider that the reason they stop responding is due to some change in the body, some kind of reaction or change in the body's response or immune function. Isn't it more likely that the bacteria that was being treated has responded? I mean this is known to happen, via resistance, or biofilm formation, or in the case of borrelia by shifting forms. So why not continue to treat the bacteria (eg. with herbs) or the downstream effects of the bacteria, rather than switching to trying to treat an unknown response in the body...
     
  9. Thinktank

    Thinktank Senior Member

    Messages:
    402
    Likes:
    209
    Europe + South East Asia
    titers of 1:400, how do i interpret that? Is it high, medium, low?
     
  10. Thinktank

    Thinktank Senior Member

    Messages:
    402
    Likes:
    209
    Europe + South East Asia
    Well, i got my Borrelia Elispot LTT result back from infectolab.

    Borrelien Elispot LTT
    Borrelia burgd. Vollantigen + 4 / ref. rage = <2
    Borrelien-OSPA/OSPC/DbpA 1 / ref. rage = <2
    Borrelien spezifisch LFA-1 0 / ref. rage = <2

    Also IgG titers of 1:400 is considered medium.

    Now waiting for the immunoblot, CD57 and co-infection results from RED labs....

    To the lyme sufferers, do you consider my results as positive or negative?
     
  11. Sushi

    Sushi Moderator and Senior Member Albuquerque

    Messages:
    7,249
    Likes:
    6,299
    Albuquerque
    Can you clarify those Infectolab numbers?

    The first one must be +4, but are the others +1 and +10?

    Sushi
     
  12. Thinktank

    Thinktank Senior Member

    Messages:
    402
    Likes:
    209
    Europe + South East Asia
    first one is +4, second one is +1 and the third one is 0. The test is called LFA-1

    Here's the translated version.

    Material: CPDA-Blood, Serum, EDTA-Blood, Heparin-Blood

    Borrelia burgdorferi Elispot LTT
    Borrelia burgd. Fully Antigen + 4 SI < 2
    Borrelia OSP-Mix (OSPA/OSPC/DbpA) 1 SI < 2
    Borrelia LFA-1 0 SI < 2

    The results of the Elispot-Lymphocyte-Transformation-Tests are an indication for an
    actual cellular activity against Borrelia burgdorferi.
    Explanation Elispot-LTT (LymphocyteTransformationTest):
    This method detects an antigen (Borrelia, Chlamydia, Ehrlichia, EBV, Yersinia) induced
    release of interferon gamma by reactive lymphocytes. In the Elispot-LTT the Tlymphocytes
    are stimulated by bacterial or viral antigens. Antigen specific release of
    IFN gamma is detected by a standardized ELISA colour technique in form of “spots”.
    The number of spots is resulted in form of a stimulation-index (SI) in comparison with a
    negative control (reference range: < 2 SI).
    Results = 2 SI (borderline) or > 2 SI (positive) mean a specific response of the Tlymphocytes
    regarding the different antigens in the Elispot-LTT. The higher the result of
    the SI, the stronger is the T-cellular immune-response in general.
     

See more popular forum discussions.

Share This Page