Dr. Roberts of Heartfixer suggests that "Vitamin E succinate, boron, and B12 are felt to stimulate SUOX activity." Although he provides no links to support these theories (and I could find none when I looked), I think that my recent experience strongly supports the link between boron and SUOX activity. Over a year and a half ago I began experimenting with high doses of Molybdenum (an important cofactor for Sulfite Oxidase (SUOX), and found that the dose required to free me of the "fuzzy-brain" feeling was 1500 mcg per day. Until very recently, this is what I have taken, with the exception of maybe two or three times that I tried lowering the Molybdenum dose, only to find that I still needed 1500 mcg. As most of you probably know, this is a pretty huge dose. Nonetheless, hair mineral analysis taken at least six months after beginning the high dose of Molybdenum indicated that my Molybdenum was normal. Over a year ago I first tried taking 6 mg of Boron. I quickly developed insomnia, which lasted for over two weeks in spite of the fact that I only took Boron the once. Recently, I began experimenting with taking the fat-soluable vitamins, and found that, to avoid a sort of mental fatigue, I needed to take Boron--however Boron continued to cause terrible insomnia. Finally, having read the above quote from Dr. Roberts, I decided to experiment with lowering molybdenum. This was based on the understanding that Sulfite Oxidase (SUOX) works within mitochondria, transferring electrons produced via the conversion of Sulfite to Sulfate and Nitrite to Nitric Oxide (particularly when tissues are hypoxic) into the electron transport chain. I reasoned that if Boron was somehow increasing SUOX activity, then maybe the high dose of Molybdenum I was taking was overdriving it, and this was adding too much to the electron transport chains in the tissues rich with SUOX. Wikipedia notes that "In mammals, the expression levels of sulfite oxidase is high in the liver, kidney, and heart, and very low in spleen, brain, skeletal muscle, and blood." This matched the particular patter of the fatigue from Boron: Wired, yet especially weak skeletal muscles, a tired brain, and poor digestion. Within days of lowering my daily dose of molybdenum from 1550 mcg to 50 mcg, my sleep returned to normal (for me), and a few weeks later I have yet to experience a fuzzy feeling I associate with excessive sulfites. In conclusion: Because Boron A) Helps with my concentration B) Prevents sulfite toxicity and C) Returns my necessary molybdenum dosage to levels that are generally considered "normal," I think that using Boron and small amounts of Molybdenum is a better way to deal with sulfites than just using large amounts of Molybdenum. Finally, in regards to Vitamin E succinate, which Dr. Roberts suggests increase SUOX activity: I took vitamin E succinate for most of the time I took high doses of molybdenum, but recently went off of it and noticed no difference in how much molybdenum I needed. If this works for other people too, then it might help to explain the fairly large variance in how much molybdenum individuals need to take to avoid sulfite symptoms. I don't think that mutations are the only issue here, because I do not have any problematic mutations in SUOX that I know of.