(Not a recommendation)
"Infectious mononucleosis" is often called "mono" or "glandular fever".
http://bmj.com/cgi/content/extract/350/apr21_2/h1825?ct
BMJ 2015;350:h1825 doi: 10.1136/bmj.h1825 (Published 21 April 2015)
Clinical Review
Infectious mononucleosis Paul Lennon specialist registrar 1 , Michael Crotty general practitioner 2 , John E Fenton professor 1
[..]
"Infectious mononucleosis" is often called "mono" or "glandular fever".
http://bmj.com/cgi/content/extract/350/apr21_2/h1825?ct
BMJ 2015;350:h1825 doi: 10.1136/bmj.h1825 (Published 21 April 2015)
Clinical Review
Infectious mononucleosis Paul Lennon specialist registrar 1 , Michael Crotty general practitioner 2 , John E Fenton professor 1
[..]
Does infectious mononucleosis lead to chronic fatigue syndrome?
Chronic fatigue syndrome is defined as severe fatigue and disabling musculoskeletal and cognitive symptoms without another explanation that lasts for at least six months and results in severe impairment in daily functioning.w47
There has been much debate about the cause of this disorder.
Some authors suggest that it is precipitated by an acute infection, such as infectious mononucleosis, as many patients relate the onset of their illness to an initial infection from which they never recovered.w48
Prospective studies have reported an incidence of chronic fatigue syndrome of 7.3-12% in adults six months after infectious mononucleosis.w49 w50
However, the relation between chronic fatigue syndrome and infectious mononucleosis is still questionable.
A study of over 1300 patients diagnosed as having infectious mononucleosis by serology, found that although 10% of patients reported fatigue none fulfilled the criteria for chronic fatigue syndrome (table 2⇓).15
The cause of chronic fatigue syndrome is likely to be multifactorial.
A trial that compared activity with imposed bed rest in the management of infectious mononucleosis found that those patients who were allowed out of bed as soon as they felt able reported a quicker recovery.w52
A brief intervention at the time of diagnosis of infectious mononucleosis to allay fears of a prolonged disease may help to prevent the development of chronic fatigue syndrome.w53
A recent editorial commented that chronic fatigue syndrome is unlikely to be a consequence of Epstein-Barr virus but a heterogeneous family of disorders arising from a constellation of pathophysiological causes.16
w53 Candy B1, Chalder T, Cleare AJ, Wessely S, Hotopf M. A randomised controlled trial of a psycho-educational intervention to aid recovery in infectious mononucleosis. J Psychosom Res. 2004 Jul;57(1):89-94.
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