Hi, I haven't posted much, because I didn't really think I had ME. That is, until I looked at a list of diagnostic criteria for ME by the International (can't remember the full name). I had pretty much everything on the list. I started 11 years ago suddenly with POTS, which pretty much left me housebound. I have declined over the years to where I pretty much sit on the couch all day. I've been to many doctors, but nothing prescribed has helped. Now on to my title for the post. About 25 years ago, I began noticing a faint blue ring in the commode in our master bedroom. We didn't use any blue colored cleaners, so I wasn't sure what it was, but was not concerned. Fast forward about 10 or more years, and I switched using bathrooms. I then used the "girls" bathroom with my daughters, and the "guys" used the master. Well, a blue ring began showing up in the new bathroom. I decided it had to be because of me, because I have a habit of using the bathroom in the middle of the night and not flushing because I don't want to make noise. So, it sits for many hours. I was still mostly not understanding it and not concerned. Fastforward to about 5 years ago, and I used the 3rd bathroom in our house right before we left on an overnight doctor's trip. I forgot to flush, and when we came home, it had a blue ring. I then made an appt. with a geneticist, because all I could find online was two possible causes and both genetic. The doctor was awful...he asked when did my last child leave the house(implying psychological issues). I asked if he could please just run basic tests on tryptophan. He agreed. I had blood and spot urine done. When the tests came back, it listed all the amino acids EXCEPT tryptophan!! How does that happen??? I tried to message and call, and they kind of blew me off, so I still don't know anything. And I just let it go. Sorry this is so long! Fastforward to two years ago. I had a hip replacement. It required me to use a bedside commode at night, as it was too far to walk safely at night with my POTS. Well, lo and behold, the paper in the commode with NO extra water like a toilet would have turned blue by next midday. It was finally proof that I, me, was putting something out in my urine that when exposed to air long enough, caused a blue film on the urine and paper. I took my pictures to a urologist and he literally blew me off. He was in the room for maybe 4 minutes and that was it. So, I am here reading about all of the posts of kynurenine and indoleamines, and I'm thinking, I thought I read those things a few years ago when researching about blue urine? So, now I'm wondering if this is a sign for me for ME, somehow that I have not a genetic issue with tryptophan, but whatever causes the tryptophan issue with ME. Any insight please? I NEED to figure this out.