If you have insurance and a willing doctor, you might be able to get half these tests done before insurance chomps. I'm not sure what Lerner et al. uses but I put a lot of research into these tests. Always stop medications, if you can, 5 half-lives before your test. It's nil-nil if you don't. Since two people have asked already, here are the tests I've had: CBC CMP ESR Estrogen CORTISOL AM ANA If you are male, you can add testosterone, LH and FSH. If curious about your plasma neurotransmitter state, you might find you have high norepinephrine and low dopamine. More than likely, this occurs because most "CFS" patients are hypocortisolemic, and more norepinephrine than dopamine must be produced to activate the adrenal glands. Dopamine has a tendency to reduce cortisol output (ie selegiline, a dopamine agonist, is used for high cortisol in dogs). Free t3 and t4 are the only relevant tests. TSH can be all over the place. Those are ones a good PCP doctor will test if you ask. Now, here are the tests I've had that I recommend (I've made some mistakes, like getting a CEA, CRP because they are just too broad). Serum protein electrophoresis = good cancer screen, immune abnormalities Thyroid Antibodies Test = tests all thyroid antibodies ACTH stimulation = for hypocortisolism DHEA = if you are low, it's a good thing to supplement Anticardiolipin Ab= obscure, to make sure I didn't have a more defined illness Anti-DSDNA Abs = obscure, to make sure I didn't have a more defined illness Aldosterone = for possible fludrocortisone supplementation Prolactin= for possible prolactinoma Allergy Testing = self-explanatory NOT FOOD, that science hasn't been worked out yet Lyme - Duh EBV Mycoplasma pneu Tumor Necrosis Factor inflammatory molecule (drug target) IL-6 inflammatory molecule (drug target) Natural Killer Cell Short NKCs kill pathogens T and B Cells gives you an idea if a treatment will work Anemia low iron causes fatigue Fibrinogen to exclude clotting disorders Tissue transglutaminase to exclude celiac STD panel w/ AIDS it's been awhile, but yes. RF Rheumatoid arthritis predictor RPR to exclude syphilis/lupus Creatine Kinase Muscle pain CMV and HHV if you are up for valcyte All of these just exclude major problems. They may not bring you any more towards a solution.