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Blood Products Advisory Committee Meeting Announcement (BPAC) December 14-15, 2010

Discussion in 'Media, Interviews, Blogs, Talks, Events about XMRV' started by Otis, Nov 26, 2010.

  1. Deatheye

    Deatheye Senior Member

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    I thought the this is the end of phase 2? But now they are talking about phase IIa and IIb? Are they both closed or is this just the end of phase IIa?
     
  2. Jemal

    Jemal Senior Member

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    Yes, I don't think XMRV is causing fatigue that quickly. Also most animals need to be really sick, before they display it openly. They don't want to show weakness, because of possible predators.
     
  3. Cort

    Cort Phoenix Rising Founder

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    Antibodies! The test Judy is really focused on...CDC negative while WPI finds some positives...this is good - they are finally getting down to brass tacks here.

    Some not very good news; both Alter/Lo and WPI report that the negative control is positive!

    Some more not very good news; both NCI and WPI find positives but in different samples - not good at all but then Judy says

    Judy appears to be saying that yes, the PCR results were off but the antibody tests identified the same samples at the WPI and NCI with XMRV. She states the WPI doesn't do direct PCR (I imagine they do only culture) - (so they're not surprised they would off here.) (They did do direct PCR for the first study- but they have apparently dropped it.?)

    That's it for now! Back after a break.

    Processing/Storage

    No evidence that not processing a sample quickly makes any difference

     
  4. Cort

    Cort Phoenix Rising Founder

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    I don't see many real conclusions......I don't even see that much testing, honestly....We'll have to wait for the CAA webinar I guess to really figure out what happened. It always seems like underwhelm with these guys...
     
  5. Esther12

    Esther12 Senior Member

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    It could be that because II came up with such difficult to interpret results they've now added in IIb before moving on.

    I don't know what to think about all this. It all seems so incredible.

    I think I'm marginally more pessimistic than before we got the BWG results, but still arround 50/50 on it. The new WPI UK paper sounded solid though.
     
  6. urbantravels

    urbantravels disjecta membra

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    Phase II inconclusive, but they're not giving up - they're adding a Phase IIb.

    I'm confused by most of this but hopefully will become more clear as more info gets out.
     
  7. Otis

    Otis SeƱor Mumbler

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    Small sample sizes is one issue here.
     
  8. Esther12

    Esther12 Senior Member

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    Actually, I do now want to take back my patronising 'how hard can it be to run some blinded tests and clear this up' whinging about XMRV. It does seem like it's pretty darn hard to work out what's going on.

    I wish they'd got on with something like the BWG a year ago though. I can't believe we're still not going to know if it's just a contaminant or not this year.
     
  9. Esther12

    Esther12 Senior Member

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    Yeah. It makes it difficult to say anything with any confidence.

    Stange that the day the sample was taken could make such a difference too.... yet the wPI seems to be getting such clear results for the Science paper and their new UK one.
     
  10. Jemal

    Jemal Senior Member

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    So... can I call it disappointing so far? It kinda looks like we moved only a few inches since october last year. Like Cort said, I can't really find any conclusions so far.
     
  11. Bob

    Bob

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    I'm confused... One sentence says that there's no concordance between WPI and NCI by serology, and then another says that there's complete concordance... Can anyone work out what's actually going on there?

    And do we have any info about the actual detection rates by the WPI and NCI in Phase IIb? Have I missed anything about that?

    Do we have any helpful conclusions from Phase IIb, or was it a complete mess?

    Have they now finished Phase II or are they continuing with Phase IIb or starting a Phase IIc? Questions, Questions, Questions!
     
  12. Ernie

    Ernie *****

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    I doubt much is going to be accomplished at this meeting.
     
  13. Jemal

    Jemal Senior Member

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    Picked up these two tweets:

    http://twitter.com/xmrvbug

    And:

    http://twitter.com/CreekFeet
     
  14. Esther12

    Esther12 Senior Member

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    I'm not really clear on the results either. It would be nice to have them concisely laid out somewhere. From the sounds of it, they're deeply ambiguous.
     
  15. Cort

    Cort Phoenix Rising Founder

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    One thing I get is that they really do realize how hard it is to find this virus....but where are the conclusions....They certainly weren't spelled out in the posts. Hopefully during the webinar we'll be able to address the members and get something definitive.....
     
  16. Riley

    Riley

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    I don't mean to be vulgar, but this sounds like a real clusterf***. Also, whose bright idea was it to only use 4 samples?
     
  17. Jemal

    Jemal Senior Member

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    At the moment I think this might be an understatement :D

    Well, I guess it's not that easy, like Esther already said. If it was easy we would already have a cure...
     
  18. Cort

    Cort Phoenix Rising Founder

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    He's saying this, I think, because XMRV is not that different sequence wise from those found in mice. The longer XMRV remains out of mice - the more it should diverge.
     
  19. urbantravels

    urbantravels disjecta membra

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    They could still, very easily, decide to defer (not just discourage) diagnosed CFS donors at ALL blood banks on the precautionary principle until more is known. Why they haven't done that already is kind of a mystery to me.

    It looks like they can't possibly call for donor blood screening yet since the assay question is still so far up in the air.
     
  20. Cort

    Cort Phoenix Rising Founder

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    It looks like they have a long, long way to go......
     

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