Okay so this is a strange question, but would you be able to feel if its been breached? Meaning, every drug/medication I take I actually can feel my brain/head burn/tingle. That is one of my worst symptoms. Also, unfortunately, my MRI shows 4 microbleeds. Common in people over 65, but not for a 47 year old. Direct evidence of neuroinflammation? No one knows. The dr.'s have no answers. And I have low vascular endolethial growth factor. Im afraid it all shows my permeability is breaking down. Anything from you scientific types? I also have low complement levels, a high IgM and my lymphocytes are way off. Its been like that for at least 14 years. A rheumy just put me on Plaquenil. My behavior has been so "off" lately, Im afraid this all impacting my brain (literally)!