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Blinding: A detailed guide for students

D

Dolphin

Senior Member
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https://twitter.com/i/web/status/879462056100900865
https://twitter.com/i/web/status/879430082397442048




http://www.students4bestevidence.net/blinding-comprehensive-guide-students/

What about when blinding is not possible?
In cases where blinding is not possible or feasible, the outcome measures must be objective! If you are reading a study that is un-blinded, with subjective outcome measures, then you may as well stop reading it and move on. This is because, if a patient is aware they are receiving the active intervention and the outcome measure is subjective, such as ‘how much pain they are experiencing’, their reporting is likely to be biased. Knowledge of the group assignment can consciously or subconsciously cause the patient to feel better and report improved subjective pain tolerance. This is not a reliable study design and the results should not be interpreted with any certainty.

It should be emphasised that the use of objective outcome measures are not a replacement for robust blinding in clinical trials. Blinding should be used wherever possible.
Click to expand...
My underlining.
 
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