I noticed some great changes after staring the Freddd protocol (FP) last October: Stabler gut Brainfog gone Less sleep Much higher energy Much better blood-sugar response Psoriasis faded somewhat Gained 3 kg (I'm skinny) High libido Halved my hydrocortisone dose Much improved motor skills, mental functioning Better exercise tolerance Then I began having problems with anxiety, which took me 3+ months to resolve. (It was carnitine, so I began titrating liquid carnitine up from tiny doses, which is working well.) I also got hit by massive reflux & gut problems - resolved via betaine hydrochloride. With all that finally under control (March), I noticed my original FP improvements had largely dissipated (despite still being on the protocol). So I got some DHEA. This normalised blood-sugar & sleep, & raised energy to its highest-ever point. I could also chelate heavy metals with ALA without any sfx. A couple of the less important FP improvements (psoriasis, libido) have gone; moreover the present improvements are from DHEA, not the FP. For half a year I've been on low daily FP doses: Metafolin 600 mg mB12 1.5 to 3 mg liquid carnitine 1500 mcg a Dibencoplex AboCbl 10g tablet every few days I still have plenty of faith in the protocol: those initial changes were very striking. Any idea what I should do next?