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Bioscreen test at newcastle uni in 1997

Discussion in 'General ME/CFS Discussion' started by knackers323, Dec 15, 2013.

  1. aimossy

    aimossy Senior Member

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    @Elph68 have you heard anything through the grapevine when they are likely to publish or good things about results out of interest.
  2. Persimmon

    Persimmon Senior Member

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    They called themselves the Collaborative Pain Research Unit, and their biomarker "breakthrough" was big news at the time. Newspapers around the world ran the story.

    They claimed to have a pair of diagnostic biomarkers, CFSUM1 and CFSUM2. These were urine tests.

    They used to carry out a range of additional blood, urine and stool tests. From this they thought they could subtype CFS patients. In addition, they profiled patients individually, with a view to being able to design individual treatment programs.

    Aside from their own lab tests, they arranged the following tests:
    Mycoplasma DNA via PCR
    Rickettsia DNA via PCR
    RNase L
    Interleukin 2

    A quick update on the Newcastle team:
    - Hugh Dunstan is still a professor in Newcastle.
    - Tim Roberts retired from Newcastle in 2008, and is now a professor in Singapore. He also flogs "Fatigue reviva", an amino-acid miracle (?) potion
    - Neil McGregor remains a practicing dentist (periodontist). He's now in Melbourne. He got into CFS via an interest in chronic pain, which was the subject of his dental PhD, I think.
    -Henry Butt was covered in earlier posts.
    Last edited: Dec 16, 2013
    MeSci and heapsreal like this.
  3. beaverfury

    beaverfury beaverfury

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    Nothing too nasty. No Prevotella, no streptococcus, no staphylococcus, zero clostridium.

    Really high enterococcus faecalis though, 87.5%. This connects to cognitive dysfunctions, sleep and altered intestinal barrier. Normal distribution is <5%.

    A few too many of some strain of bifidobacteria and eubacterium.

    For bifidobacterium i've taken ampicillin, which is also part of my lyme/coinfection regime.
    My stomach improved rapidly. It reduced the burning feeling and made my stomach a bit more robust towards food.

    For E.coli they suggested supplementing with galactose ( a sugar found in lactose free milk).
  4. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    I wonder whether the work is funded by the Arab multi-millionaire Sheikh Yabouti...:D
    beaverfury, heapsreal and aimossy like this.
  5. aimossy

    aimossy Senior Member

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    @beaverfury do you mean to up the E.coli galactose is good to increase levels that are too low? just making sure I got that right:)
  6. Elph68

    Elph68 Senior Member

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    Sorry aim,

    All as they said was they had finished their current CFS study and were probably going to do Sleep disturbance next ....
    aimossy likes this.
  7. beaverfury

    beaverfury beaverfury

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    Yep, that's right.

    They wrote, "Consider supplementing oral sugars (galactose, fucose) to increase the densities of current intestinal coliforms (eg E.coli) as opposed to adding a different strain with probiotics.
    Recent supplementation with fructo-oligosaccharide (FOS) may also have suppressed growth of this organism. "

    That's 'fucose', not fructose.

    Where do you get that from in pill form you say?
    ..I have no idea.
    But theres quite a bit of galactose in lactose free milk.

    I've tried mutaflor before. It seemed to coincide with me getting quite anxious and edgey.
  8. aimossy

    aimossy Senior Member

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    haha thanks for that!!!!
  9. knackers323

    knackers323 Senior Member

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    Did you notice an improvement in your fatigue?

    Have you retested to see what the levels of the gut bugs are now?
  10. beaverfury

    beaverfury beaverfury

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    Yes, fatigue has absolutely improved. But i am taking four lots of antibiotics for lyme/coinfections as well, so it's impossible to tease out what is doing what.

    I haven't retested yet. Bioscreen does give you a discount on the retest.
    aimossy likes this.

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