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Biopersistence and brain translocation of aluminum adjuvants of vaccines

Discussion in 'Latest ME/CFS Research' started by A.B., Feb 7, 2015.

  1. A.B.

    A.B. Senior Member

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    I came across this interesting article today:

    http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00004/full
     
    Gondwanaland, melamine, jepps and 5 others like this.
  2. Jon_Tradicionali

    Jon_Tradicionali Alone & Wandering

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    Zogor-Ndreaj, Shkodër, Albania
    Good find.
     
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  3. picante

    picante Senior Member

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    This study would never have received funding in the US or UK.
     
  4. alex3619

    alex3619 Senior Member

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    There was a thread here discussing MF some time ago. Was this the same research or a new study? This is an idea that will be fought by vested interests whether it is right or not.
     
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  5. Hip

    Hip Senior Member

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    Some info here about the possible connection between autoimmune diseases and the aluminum hydroxide adjuvant in vaccines.
     
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  6. barbc56

    barbc56 Senior Member

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  7. adreno

    adreno PR activist

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    Silicon might help remove aluminum:

    http://www.ncbi.nlm.nih.gov/pubmed/22976072
     
    Last edited: Feb 8, 2015
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  8. A.B.

    A.B. Senior Member

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  9. A.B.

    A.B. Senior Member

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    This is also interesting:
    Do they really mean the ICC? Unfortunately the references are behind a paywall.
     
  10. chipmunk1

    chipmunk1 Senior Member

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    i think it is interesting but but what irritates me is the fact aluminum is abundant in the earth crust and taken up by plants and thus animals etc.. we consume rather large amounts of aluminum and always have. thus the human body should have some ability to get rid of the metal.

    the vaccines contain only a very tiny amount of aluminum very little compared to our daily intake. the fact that it is injected means that it far better absorbed than usual but it is still a one-time event.

    so how is the aluminum that is in vaccines different from the aluminum in foodstuff and why should the former be far more harmful?

    i don't doubt that it is toxic but it is a fairly common element and we get exposed to it when we drink a can of coke we eat vegetables etc. if there were an effect i doubt that this could be due to toxicity rather than immune activation triggering a pathological immune response or something like an "allergic response"

    Daily aluminum intake is estimated to be around 7mg per day.(much of this is not absorbed). The total body burden of aluminum in healthy human subjects is approximately 30–50 mg. Normal levels of aluminum in serum are approximately 1–3 μg/L.:

    A vaccine might contain 0.25-1 mg. Perhaps infants would be at risk but i don't see how an adult could reach a toxic body burden with this.

    half-life of alumnum in the human brain is estimated to be seven years.
     
    Last edited: Feb 8, 2015
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  11. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    Was it this paper? I looked briefly for a thread discussing it but didn't find one, although I found a few others.
     
  12. Marco

    Marco Grrrrrrr!

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    Very interesting. Thanks. Could this be added to @Jonathan Edwards list of 'ME's' I wonder?

    This is another earlier short paper cited by the current one :

    Chronic fatigue syndrome in patients with macrophagic myofasciitis

    http://onlinelibrary.wiley.com/enhanced/doi/10.1002/art.10740/

    I'm also sceptical as to whether this 'MMF' theory has any traction amongst the wider scientific community not to mention any subsequent link to systemic disease although the WHO have at least reviewed the evidence at the time (1999) :

    "Regarding the potential linkage of the local MMF lesion with systemic disease, the following points were made. MMF lesions have been detected in patients undergoing deltoid muscle biopsies for investigations of diffuse myalgias, arthralgias or muscle weakness, and in whom there is a history of administration of an aluminium-containing vaccine at some time in the past, the interval varying from months to several years. In a proportion of patients there was also evidence of a concurrent autoimmune disorder. Research on the potential association with autoimmune diseases was strongly encouraged.

    At present, within the constraints of current knowledge, MMF does not fall within the disease entities of inflammatory myopathy, dermatomyositis, polymyositis, inclusion-body myositis or eosinophilic fasciitis. The current evidence neither establishes nor excludes a generalized disorder affecting other organs.

    The small sample size on which these observations are based, together with the absence of data regarding the prevalence of local MMF lesions in the general population after vaccination, makes it difficult to assess potential links between local MMF and systemic disease. A more specific set of criteria and definitions needs to be determined in further epidemiological studies to establish whether there is an association between local MMF lesions and any systemic symptom or condition. The immunological mechanisms which might be involved in transforming a local immune reaction into a systemic disorder are numerous and need further investigation."

    http://www.who.int/vaccine_safety/committee/reports/october_1999/en/
     
  13. Marco

    Marco Grrrrrrr!

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    From my reading of the paper it is the crystalline structure of the aluminium salt (alum) used as the adjuvant that may be the problem as opposed to soluble aluminium (which I suspect is the form naturally absorbed from the environment).

    The inability to clear the alum or SNPs related to related chemokine signalling in a small number of susceptible individuals is also proposed as explaining why not everyone has ill effects.
     
  14. alex3619

    alex3619 Senior Member

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    MF is not yet close to being fully established, its still an hypothesis, though the evidence is growing. However, its not about consumption of aluminium, and not about quantity. Its about concentration injected directly to provoke the immune system. Its an adjuvant. We absorb little from the gut, but this bypasses even that defense. If it did not induce immune issues it would not be an adjuvant.

    What they are describing is already known with tattoos. Its resident macrophages etc. that absorb the tattoo ink that hold it in the skin. So the absorbed aluminium is a little like an invisible tattoo that makes you sick if the hypothesis is correct.
     
  15. Marco

    Marco Grrrrrrr!

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    Just to be clear I'm not suggesting that this is the cause of all or even any cases of ME/CFS. I'm more interested in the mechanism by which a peripheral immune event can trigger a central systemic illness with very similar features to ME/CFS.

    On the other hand - who has a tattoo? ;)
     
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  16. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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  17. Marco

    Marco Grrrrrrr!

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  18. alex3619

    alex3619 Senior Member

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    http://www.behavioralandbrainfunctions.com/content/11/1/6/abstract

    Beraprost sodium protects against chronic brain injury in aluminum-overload rats

    I am not suggesting this as a treatment, but look at the physiology associated with aluminium in the brain. Low SOD is one issue that might be very relevant. This is a chronic brain injury treatment.
     
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  19. Sidereal

    Sidereal Senior Member

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  20. chipmunk1

    chipmunk1 Senior Member

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