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Nitric oxide and its possible implication in ME/CFS (Part 2 of 2)
Andrew Gladman explores the current and historic hypotheses relating to nitric oxide problems in ME/CFS. This second article in a 2-Part series puts nitric oxide under the microscope and explores what it is, what it does and why it is so frequently discussed in the world of ME/CFS....
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"Biomarkers revealed as red herrings are still treated like smoking guns"

Discussion in 'Other Health News and Research' started by Dolphin, Jun 3, 2011.

  1. Dolphin

    Dolphin Senior Member

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    John Ioannidis was one of the authors. He's an interesting researcher in my opinion. He has a degree in mathematics. He often challenges the status quo.

     
  2. Dolphin

    Dolphin Senior Member

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    Abstract

    Here's the abstract - but the other article is easier to read

     
  3. Esther12

    Esther12 Senior Member

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    Thanks.

    Reminds me of the "CFS = Depression" meme which is still going strong amongst doctors, despite the fact that the researchers like Wessely who had promoted it have long since abandoned it. (Isn't there some Wessely quote like: "Whatever's wrong with these patients, it's not depression.")

    It's a pain.
     
  4. Snow Leopard

    Snow Leopard Senior Member

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    Australia
    Ah, John P. A. Ioannidis of "Why Most Published Research Findings Are False" fame.
    http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0020124


    "Comparison of Effect Sizes Associated With Biomarkers Reported in Highly Cited Individual Articles and in Subsequent Meta-analyses":
    http://jama.ama-assn.org/content/305/21/2200.short

    The whole scenario of the relative risks being magnitudes of order in the highly cited papers (published in top journals), compared to the subsequent meta-analyses is a clear result of publication/citation biases.
     

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