It depends on the brand. The serra brands I had tried in the past didn't work at all.so is serrapeptase and natto not worth buying,
However I recently tried a Serra that was cultured from Serratia marescenes (the one used in studies) and it definitely had an anti-inflammatory effect within hours. If the label doesn't say anything about the source of the enzyme (eg. dr best), it's not worth trying.
As regards natto, I only had some results from a brand not available any longer. Here it's probably again a question of source and dosage, only at high dosage it seemed to work.
Concerning Lumbro the only brand that worked for me was Boluoke, unfortunately it was quite expensive and I only used for brief periods of time.
Of them all, Boluoke was the one that worked best for me.
No idea.how does phosphitadylcholine work synergistically with antibiotics?
I don't know to what extent these enzyme actually break down biofilm. What I know is that they (Boluoke esp.) did make a difference in my case. Regarding asthma and COPD I don't know, sorry, my knowledge is limited to my own experience with Lyme/Cpn.and lumbrokinase is better for biofilms and asthma/COPD?
Best wishes.