Since mid September I've been doing Cellular Health Analysis (bio-impedance) testing at my chemist and on a consistent basis I'm getting high Fluid Retention Factor (FRF) in the ranges the Dr normally only see's in those who are hungover or officially recognised as having chronic fatigue. That is, between 35 and now 52% I'm really at a loss as to why i'm getting these consistently high results which I'm told are an indication of 'toxicity' Previously I've had elevations in the 40-45% range and then by the omission of a certain 'agents' I found the results returned to the 'normal range' of 15-25% I don't think I'm particularly toxic... indeed I find it hard to believe there'd be much toxicity left at all after all the years of healthy eating / chemical avoidance I've been employing to overcome my general lack of energy.. Therefore I think its probably best to consider whats happened since the end of May when I had my last 'normal' result of 22% on the fluid retention factor (toxicity) From 1 June I would do coffee enema's once a week consistently till early September (3 months) On July 10 I commenced a methylation protocol using SAM-E (200mg), MeB12(1mg sublingual) and 5-MTHF (1mg) and within a few days I noticed symptoms which I now recognise as the startup symptoms: angular chelitis (cracking at sides of mouth), acne, and emotional lability. I continued this protocol and then reduced the intake of folate and B12 substantially in about early September taking just 1mg of B12 every 5th day and 1mg of folate once a day. In early October I got blood test results which showed a slightly elevated AST reading but other enzymes all normal. From 8 November onwards I commenced an amended methylation protocol based around the deadlock quartet hypothesis and with MUCH higher doses of folate (up to 7mg a day and 10mg B12) but omitted the SAM-E. I didn't get any acne or angular chelitis but felt fatigued in the extreme until I significantly reduced my folate intake. This was my first intake of Alpha Lipoic Acid too, but remember my high FRF was happening before this new supplement. What is the validity of the fluid retention factor as an accurate measure of 'toxicity' ? I've not been able to find anything helpful in google searching. I feel there must be some merit to it given my simultaneously high liver enzyme results (AST) but then I think of all my years of healthy living and struggle to believe I could have any appreciable toxicity. Is it possible that the methylation protocol I commenced in July has led to my body 'finding' hidden stores of toxins that have now been moved into other parts of my body? To give you more history: I've had hair analysis done in 2009 and 2010: the only abnormal result was Aluminium which wasn't too severe. More importantly I ceased the intake of the possible cause by buying organic Sea Salt (minus that anti caking agent which contains the Al) and regularly consumed curries filled with Black pepper/Cumin/Turmeric along with chlorella. I did 2 months of Far infra red sauna's and led an extraordinarily clean diet with ample Zinc supplementation and sulfur from dietary garlic. At no point did I notice any 'detox' symptoms and given my consumption of a super healthy diet since 2002 (just 21 years old) and heavy zinc supplementation going back to 2002 I think its safe to assume I hardly had any heavy metal burden. Why do I have this high fluid retention factor!!! I was so upset at seeing the 52% result I got today that I saw a GP later in the day who has given me a 2nd test sheet so I can re-test those liver enzymes but has also included serum ferritin and ceruloplasmin to check into iron or copper I'm guessing... Has anyone else run a methylation protocol whislt monitoring their progress using the bio-impedance measure, or indeed any kind of detox protocol? Did the fluid retention factor change much? It seems a valid measure: first being used by NASA to monitor health of their astronauts, so I think it might have credibility, but my results don't make sense.... Is Vitamin D supplementation of 6000IU a day since June enough to cause a problem like this? as you can see I'm at a complete loss to understand it... yet I feel it might be quite important... Any advice would be appreciated.