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"Bias in research: the rule rather than the exception?" referenced piece by 2 Elsevier editor

Discussion in 'Other Health News and Research' started by Dolphin, Sep 21, 2013.

  1. Dolphin

    Dolphin Senior Member

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    September 17 article. Just a general article, no reference to ME/CFS specifically, although parts could certainly be relevant.

    Shorter than most papers (1633 words which includes counting reference numbers). I didn't notice any math/stat or biological terms, although I suppose a piece like this could be perhaps a little abstract for the odd person who hasn't read anything about the area.

    http://editorsupdate.elsevier.com/i...-research-the-rule-rather-than-the-exception/
     
    biophile, Simon, Sean and 1 other person like this.
  2. Esther12

    Esther12 Senior Member

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    As cause of bias, I think that the animosity around CFS (much of it prompted by earlier bias!) is likely to be a factor with research in this area.

    Imagine if the PACE trial had released the original recovery criteria, where any increase in 'recovery' rates for CBT and GET may not have reached statistical significance. People would have been rightfully furious. That these interventions were being confidently promoted to patients long before there was a sufficient evidence base makes it much harder for those responsible to now release honestly presented data showing how little use they are.
     
    Valentijn, Roy S, biophile and 2 others like this.
  3. Simon

    Simon

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    Monmouth, UK
    Thanks, Dolphin
    Some highlights for my benefit:
    Especially liked this from Sydney Brenner, one of the founders of molecular biology, who said
    I think this fits more in the sloppy than the deliberate, and much of it is probably subconcious - but still bad science.

    In the stats course I did, the (psychology) prof was very critical even of using the null hypothesis: for him what you needed to show that your idea wasn't 'better than nothing' but better than some credible alternative. And I think that lack of searching for plausible alternative explanations is a big problem in CFS research. Just one example is lazy interpretation of 'negative personality' findings, which ignore the likely effect of illness on the way people answer questions (eg my life has no meaning) - when the questionnaires involved were developed in healthy populations.

    Finally, I loved this quote:
     
  4. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    Esther12 , is there call for a short paper using the early PACE criteria, and giving an adjusted outcome? Can this be done without the raw data? I suspect not.
     
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