http://www.ncbi.nlm.nih.gov/pubmed/12131069 I'm coming to the conclusion that yeah if food allergies, hormones, and infections are coming back good then it might be time to consider the body's deficiency in mounting a stress response (which includes beta endorphin production). My pituitary produces no hormones. Yet, I have replaced all of the hormones I was told I needed to replace. Little did I realize that the primary endorphin is indeed made in the pituitary. Here I have a study showing "significant decreases" in beta endorphin in fibromyalgia AND Chronic Fatigue patients. Pop half a vicodin (which I was rxed) and boom, motivation to withstand the world. The OI, the everything else, could possibly just be a compensation/defense mechanism response to the body basically realizing that it cannot handle stress. Now you might ask why isn't this further researched? Probably because our governments make billions in tax dollars if not more of making opiates and other drugs illegal. It's no wonder most of us started out depressed and unable to withstand stress before completely breaking down. Perhaps we were beta endorphin deficient from the start. And as for LDN, please don't say...oh well I didn't respond to LDN so this isn't true. You guys know LDN blocks opiate receptors and will only work if your pituitary can make more beta endorphin the next day? The LDN approach is only to be used on people who have some sort of signaling problem, not people who have genuine inability to produce beta endorphin.