I've been on Propranolol for nearly a month. The first two weeks were really good - I was able to do more and felt better. The drug worked so well that I could pinpoint exactly when it wore off. The last two weeks, however, have been dreadful. I've been struck with profound leg weakness (similar to that during my onset of illness). I'm hardly able to be on my feet at all, and when I am I'm quite shaky and unsteady and fear my legs will give out. Usually during a crash I will have some leg weakness, but nothing this bad. I assumed I was in a crash, but as it is ongoing, I'm suspecting this may be a side effect of the propranolol. Did anyone else experience this? Did switching to a cardio-specific beta blocker (atenolol) help? How long did it take for the weakness to go away once you stopped/switched? I have failed on midodrine and florinef, and thought I had finally found the silver bullet. If the beta blocker is also a fail, what next? I fear I'm running out of options. Is anything straightforward with ME/CFS??? My next appointment with my ME doctor is about 2 weeks away, and I'd sure like to have some ideas before then. Thanks!