After failing on midodrine and florinef for POTS, I've just begun propranolol 5 mg. So far, so good. My heart rate is a comfy 58 sitting and stays under 80 when I'm up. (miracle!!!) I no longer feel my heart pounding and my head isn't bobbing in time with my heartbeat (I'm a living bobble head!) I also feel calmer, like my body isn't on a high speed adrenalin rush, which in my case is a really good thing; a good thing I hope can translate to less energy used on autonomic functions and more on daily tasks. However, my BP is a little concerning. My sitting systolic has stayed the same (138) but my diastolic has gone up from 83 to 98. The good news is that BP stays stable when I'm up (normally my pulse pressure drops like a rock to around 10) I noticed in a recent post (no clue where ) that beta blockers are ranked as the number one worst treatment experience for most PWME, which concerns me. Does anyone have experience with beta blockers? I'd love to hear your tales, both good and bad. For example: Do you use as needed, or every day regardless of symptoms? Do you combine with other dysautonomia meds? Did you have success with BB's initially, only to have them fail within a short time? Etc. Thanks so much!