Hi, A very good online friend of mine is suffering from (what she believes to be) CFS. She doesn't have autonomic symptoms such as POTS etc.; I believe the primary issue is physical fatigue, which she tends to find worsens with exertion, e.g. if she spends a day cleaning the house, she will pay for it for the next 3-4 days. She is currently taking 10mg of Lexapro for long-term anxiety/depression and Adderall as needed, though the effects are hit-and-miss. I looked over some of her bloodwork and the thing that stood out was a raised TSH (~4.5 if I recall correctly) and I've suggested she sees an endo, but I think she is feeling too overwhelmed and hopeless to organize a lot of this stuff. I'm just wondering what she should be doing regarding the basics of supplementation, particularly if she's not so severe that she can still tolerate stuff. I told her to start taking Vit D, Magnesium Malate and Methyl-B12, which she's doing so far. 1. If she's taking Methyl-B12, should she be taking B-Complex w/ Folate as well? Can the Methyl-B12 alone be increasing her potassium demands? Trying to come to terms with Methylation for my own needs gave me such a headache -- and she seems less versed with experimenting with supplements etc. -- that my fear was introducing a low-ish dose of Methylfolate (i.e. what's in a B-Complex) might be more harmful than beneficial. 2. Would it be too risky to suggest experimenting with something like resistant starch? When I wasn't doing so badly, I remember it having dramatic effects on sleep, anxiety and mood; though I don't want to risk messing her microbiome up (further).