Elizabeth Milo possibly this might help: http://www.cfstreatmentguide.com/1/...nd-cfs-99-of-patients-not-getting-better.html everyone is very individual. unfortunately I agree that you might have to try a few things before finding something that works. If you have a really smart doctor or pharmacist, they might be able to suggest something based on your case history (e.g. specific symptoms and what medications you have not tolerated in the past). I have this one doc who is a genius like that.