I was not sure whether to put this in MCAS vs. Mold/Biotoxin forum so hopefully both sets of people will see it. I have been blessed (heavy sarcasm) with both severe MCAS reactions to food and meds as well as 2+ years of severe mold exposure. Long story short, I have now seen an MCAS specialist (allergy/immunology but Masto stuff is his specialty) plus a top mold specialist which was not easy to pull off being this ill but I did it. The mold dr wants me (in an ideal world) to take binders such as activated charcoal, CSM, Bentonite Clay or Chlorella plus try nebulized glutathione. However b/c of my MCAS reactions which at their worst led me to a five day hospitalization, she has not given me permission to start any binders yet until she speaks with MCAS doctor and I tried all week to coordinate this but no luck so far. In any case, my question is... Is there anyone on PR who at any point was in my situation and if so which mold/mycotoxin binders did you find to be the best and SAFEST given your MCAS reactions. My mold Dr's concern which I share is that you must take binders 90 min from all other meds (in both directions) so three hours total. If you have an MCAS reaction within that window and took Benadryl or Zyrtec or any oral med, it will be ineffective. I know I can take a shot or even use EpiPen in a true emergency but for many reasons this is not a reasonable ongoing daily solution. I also have five different sets of meds that I take so I can't even figure out where to take the binder (logistically) but that is a separate issue. It is supposed to be twice a day 12 hrs apart and we made a spreadsheet but got no where! I welcome any thoughts on this and hoping I am not the only one with both MCAS and severe mold exposure here. I have posted on some Masto boards too but the people there were unable to take mold binders for this reason which was my fear. If I really took them twice, there would be a six hour window each day that the MCAS meds would be ineffective which scares me. Thanks for reading!