I took some berberine today, and it REALLY helped my joint pain. Naturally, I'm wondering what the catch is 1. Is it safe for long-term use? I know that it can kill pathogens, so I'm thinking it might kill GOOD bacteria, too. 2. It's a COX 2 inhibitor - so, does it screw up your digestive tract like other COX 2 inhibitors? thanks.